False positives tend to be particularly problematic in genomic or proteomic studies where many candidates must be statistically tested. Such studies may include identifying genes that are differentially expresse
Replace, reduce, refine: adhering to the 3R principles is nowadays key to good scientific practice in animal research all over the world. Briefly, the framework is based on the idea that if animals were to be used in scientific experiments, every effort should be made to ‘replace’ them w...
Here’s one way BMA might work: Let’s say a patient has a rare and often fatal form of brain cancer. Using BMA, clinicians could enter all the biological information about that patient into the system. Then, they could use the system to run all sorts of experiments, comparing the cance...
You can begin doing preliminary research once you have chosen a research topic. Two objectives should be accomplished during this first phase of research. First, you should undertake a preliminary review of related literature to discover issues that scholars and peers are currently discussing. With t...
Emma Mason is the founder and director of Cambridge Technical Content Ltd, based in the U.K. Since graduating with a bachelor’s degree in biology from the University of Kent at Canterbury in 2000, she has gained extensive experience developing and running immunoassays within companies including ...
In both experiments, laypeople seeking to make a health-related decision read pairs of conflicting Internet documents from different sources about a medical topic (cholesterol). While the description of the source of the first document was held constant, we varied the description of the second ...
individual patient, rather than relying on static, predetermined processing functionality (Wu et al.2008). In addition, smart wearables must take into account further contextual factors to increase individualization and predictive performance (Andreu-Perez et al.2015). Users should be able to adjust ...
This sample size was preregistered1 and was fixed to be identical across all experiments reported here. Four subjects were replaced based on predetermined exclusion criteria reported in Section 2.1.5 Exclusions. 2.1.2. Apparatus The experiment was conducted with custom software written in Python with...
In theory, researchers should be able to re-create experiments, generate the same results, and arrive at the same conclusions, thus helping to validate and strengthen the original work. However, reality does not always meet these expectations. Too often, scientific findings in biomedical research ...
5c). Of the four models, the online/pretrained model was unique in achieving near-maximal precision with very few manual ROI (Fig. 5e). All of these results were confirmed with a different set of experiments on a LiveCell image category (Fig. 5f–j). In both cases, 100–200 manually ...