In a) cytotoxic cells (defined as GZMA+, NKG7+, CD94+), whose mRNAs resulted increased by Imatinib; in b) NK cells (CD56 bright), that increased after Imatinib treatment; in c) mast cells (defined as CPA3+, tryptase+, MSGA2+, CCL22+), whose RNAs were decreased by Imatinib; in ...
Model validity. Models can be considered for their face validity, whether they look right; their construct validity, whether they arise through the right mechanism; and their predictive validity, whether the results in the model will translate to humans. None of these measures of validity are abso...
The researchers found it has two novel responses to extreme cold temperatures: it can switch its metabolism from respiration to ethanol fermentation as its main pathway, and can overexpress molecules called small non-coding RNAs (sRNAs) that help regulate which genes are expressed after transcription...
While precisely editing the DNA in a cell's nucleus (blue) has become easier thanks to advances like CRISPR/Cas-9, it's been much harder to edit DNA in the mitochondria (red). Now, a new tool brings precision gene editing to mitochondrial DNA. Credit: Tslil Ast/Mootha Lab Scientists ...