A 32-year-old G1P0 Ghanaian woman with HbSS is 10 weeks pregnant. She developed a left femoral vein deep venous thrombosis at age 26 years during a hospitalization for VOC, and was treated with low-molecular-weight heparin (LMWH) followed by warfarin for 6 months. She has not had recurrent...
The mechanisms by which parental histones are removed from the old DNA and reassembled onto the newly-replicated DNA largely remain a mystery. Models for inheritance of histone post-translational modifications through replication One idea that was briefly favored for the epigenetic inher- itance of ...
Carefully blot your hair instead of rubbing it quickly with a towel. You can also gently wrap your hair in a small micro-fiber hair turban or an old T-shirt. This is gentler than using a huge bath towel. 10. Use a Heat Protectant Spray If you do use a flat iron, curling wand, or...
New Thoughts on an Old Dogma Over 36 000 papers addressing p53 function have been published since its discovery 25 years ago. By contrast, a fraction of this number has dealt with Mdm2 and MdmX, which partly reflects their more recent discoveries.19, 57, 108, 109 However, Mdm2 and MdmX...
Cancer is a hyperproliferative disorder that is usually treated by chemotherapeutic agents that are toxic not only to tumor cells but also to normal cells, so these agents produce major side effects. In addition, these agents are highly expensive and thus not affordable for most. Moreover, such...
17. De Clercq E: Another ten stories in antiviral drug discovery (part C): "Old" and "new" antivirals, strategies, and perspectives. Med Res Rev 2009, 29:611–645. 18. De Clercq E: The next ten stories on antiviral drug discovery (part E): advents, advances, and adventures. Med ...
There is a growing number of association studies exploring the gut microbiota’s possible role in memory, learning, anxiety, stress, neurodevelopmental and neurodegenerative disorders. Consequently, attention is now turning to how the microbiota can become the target of nutritional and therapeutic ...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is regarded as a threat because it spreads quickly across the world without requiring a passport or establishing an identity. This tiny virus has wreaked havoc on people’s lives, killed people, and created psychological problems all ove...
For instance, one of my sojourn cohort members Shameer, a 19-year-old motor mechanic, was a newbie and did not even own sunnah attire before he joined the jamaat. He had especially borrowed the shalwar kameez for our sojourn: Shameer: I have decided to change (the style of my clothes ...