As a result, TMB is largely seen as a potentially useful biomarker but is not routinely applied in current clinical practice. From our perspective, if TMB happens to be known and is high, we would consider use of nivolumab plus ipilimumab, particularly in patients who are PD-L1-negative, ...
While the microbiome is often associated with diseases of the gut, mounting evidence indicates the microbiome plays a role in a wide range of diseases. Several investigations are under way to explore the potential link to cancer, including a recently-announced $25 million study funded by Cancer...
immunization with live avirulent deficiency has not yet been identified in humans, it seems likely that the phenotype will be much more complex and profound than that of the FcR deficiency described here, because the human FcR is expressed by additional cell types, namely T and NK cells (...
Nevertheless, the term polymorphism is also not well defined as it always refers to the size of the reference population, thus there is no distinct definition how often a mutation must occur in how many individuals before being promoted into the rank of a polymorphism (14). As an example, ...
Given the contrast to the clinical effectiveness papers, there is a question as to whether adjusting for subsequent lines is being left to be considered by those that evaluate the intervention for HTA review, which often requires cost-effectiveness to be fully analysed, rather than at the ...
Surgery is usually the first treatment option for epithelioid mesothelioma. Because epithelioid cells spread slowly, tumors are often contained to one area of the body. However, patients who are older or who have health issues may not qualify formesothelioma surgery. ...
It is often combined with chemotherapy to boost its effects. For instance, doctors might use radiation and chemotherapy together to shrink a large tumor so it’s easier to remove surgically. Radiation may also be used before or after surgery to help lower the risk of cancer recurrence. (4) ...
Most often patients, especially those in the East, receive both treatments. Chinese medicine is also commonly used to reduce side-effects from chemotherapy or radiation therapy, to aid recovery after an operation, to palliate symptoms and to address survivorship issues. However, this raises concerns...
NTG HN005 study plans to randomise 711 HPV OPSCC patients to compare 70 Gy over 6 weeks with high dose cisplatin days 1 and 22, with 60 Gy over 6 weeks with high dose cisplatin days 1 and 22 or 60 Gy over 5 weeks with nivolumab. The question arises then, while waiting for the re...
While head-to-head studies are needed to determine definitively which agents are superior, it is interesting to note that patients in the trials of pomalidomide and carfilzomib had often received several lines of targeted treatment, whereas they had received only one or two previous lines of ...