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Conversely, if the fall in PNa levels is gradual, such as in the setting of chronic hyponatremia, the brain cells are able to elicit counteracting mechanisms in order to fend off any excessive water uptake. The most immediate response consists in the shifting of liquid from the interstitial spa...
It should be stated at the outset that much of the data regarding the role of microglia in AD has been obtained from in vitro and non-human animal studies or AD patients post mortem, and their role is still a source of debate [140]. However, the use of in vivo neuroimaging techniques...
The mechanisms responsible for the release of the precursors from the plastid and the ER have not yet been identified, while much information regarding the GA movement across the plasma membrane is available. Indeed, GA moves between cells through different mechanisms, with the ion trap being the...
We are very much indebted to all anonymous reviewers and our colleagues from the lab on DNA technologies, PCR analysis, and creation of DNA insecticides (V.I. Vernadsky Crimean Federal University, Department of Molecular Genetics and Biotechnologies), from the lab on cell technologies and creation...
Since ONOO− is relatively long-lived, it can reach critical in(ex)tracellular targets located at distant locations. Much of the vascular and tissue injuries observed in certain models of inflammation are inhibited by either SOD or NOS inhibitors, suggesting that both O2− and NO are ...
ASICs are sensitive to inhibition by amiloride and are permeable to Na+ to a much greater extent than to K+ and Ca2+. For a long period, ASIC channels remained enigmatic ”brain” Na+ channels with known ENaC homology. The discovery of H+-gating of these channels propelled subsequent ...
Much, however, remains to be learned about the optimal size of a vaccine carrier/adjuvant. It depends on parameters such as the route of immunization since different populations of APCs are targeted when the vaccine is injected into different tissues (reviewed in [41]). Not only the particle ...