How do mitochondrial genes get into the nucleus?How do mitochondrial genes get into the nucleus?Cell biologyEvolutionGeneticsMicrobiologyIt is well known that genes from chloroplasts and mitochondria were transferred to the nucleus many times during plant evolution. But in what form do the transferred...
chemical tags in the genome. “It was astonishing that the epigenetic pattern between untrained and trained muscles is totally different and that many of these modifications occur in key genes that control the expression of numerous other genes,” emphasizes Furrer. Hence,...
(2009). Mitochondrial quality control: insights on how Parkinson's disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis. J. Bioenerg. Biomembr. 41, 473-479. Das, G., Choi, Y., Sicinski, P., and Levine, E.M. (2009). Cyclin D1 fine-tunes ...
Mitochondrial genome The human mitochondrial genome, while usually not included when referring to the "human genome", is of tremendous interest to geneticists, since it undoubtedly plays a role in mitochondrial disease. It also sheds light on human evolution; for example, analysis of variation in t...
We use this framework to assess existing data and to ask the question, “How many distinct primary structures of proteins (proteoforms) are created from the 20,300 human genes?” We also explore prospects for improving measurements to better regularize protein-level biology and efficiently ...
Mitochondrial topoisomerase I sites in the regulatory D-Loop region of mitochondrial DNA. Biochemistry 47, 11196–11203 (2008). Article CAS PubMed Google Scholar Kaguni, J. M. & Kornberg, A. Topoisomerase I confers specificity in enzymatic replication of the Escherichia coli chromosomal origin. ...
SCs play a crucial role in providing nutritional support to GCs via a mTOR mechanism. Rapamycin (mTOR inhibitor) can alter several metabolic parameters, including glucose consumption and mitochondrial complex III protein levels in human SCs30. mTOR dysregulation has also been associated with the onset...
DNA methylation is also reported to cause mitochondrial dysfunction in tumor cells. Tumor redox balance and the accumulation of HIF have also been widely reported to be associated with aerobic glycolysis, and DNA methylation has been found to play a regulatory role in these processes. The PPP and...
γδ T cells may actually exceed >50% of all T cells and thus constitute the dominant T cell population in certain tissues and species, for instance in ruminants and chicken (especially in early life), in the mouse epidermis, and in human blood during microbial infection [[1], [2], [...
PIK3CA is one of the most frequently mutated genes in cancer; the PI3K pathway is altered in a large number of cancer types, driving cell signalling, growth and metabolism, and PI3K inhibitors have been in development for over four decades. Seven drugs that target the PI3K pathway have receive...