The major concern regard- ing anti-RhD Ig therapy is the occurrence of rare but life-threatening episodes of severe intravascular hemoly- sis with acute renal failure and disseminated intravas- cular coagulation (DIC). Anti-RhD Ig is not widely used because it is not available in many ...
there are still unmet needs with regard to the short- and long-term efficacy in many relapsed or refractory cases. A multicenter retrospective cohort study indicated that patients who failed splenectomy, rituximab, romiplostim, and eltrombopag had significantly increased morbidity and mortality, and the...
Hematopoietic transplantation is the preferred treatment for many patients with hematologic malignancies. Some patients may develop invasive fungal diseases (IFDs) during initial chemotherapy, which need to be considered when assessing patients for transplantation and treatment posttransplantation. Given the ass...
The pathophysiology of mitochondrial DNA (mtDNA) diseases is caused by increased cell death and dysfunction due to the accumulation of mutations to mtDNA. While the disruption of oxidative phosphorylation is central to mtDNA diseases, many other factors, such as Ca2+dyshomeostasis, increased oxidative ...