Chemotherapy is a powerful treatment, but it can cause many side effects. This is because it also kills fast-growing healthy cells, not just cancer cells. Everyone responds to chemo differently. Some people have only mild side effects, or none at all. Others might have one or two more seve...
We should be suspicious of chemoresistance if there are no significant changes clinically according to the Response Evaluation Criteria in Solid Tumors and World Health Organization criteria or pathological changes according to the Miller and Payne criteria, especially after 2–3 cycles of chemotherapy ...
In CRC patients, however, an imbalance of the gut microbiome (dysbiosis) is present. It has therefore been suggested that bacteria interfere with the molecular mechanisms underlying CRC. Many effects of CRC-associated bacteria have been described (Box 1); however, the underlying pro-oncogenic ...
Extracellular vesicles (EVs) are emerging as critical mediators of intercellular communication in the tumor microenvironment (TME), profoundly influencing cancer progression. These nano-sized vesicles, released by both tumor and stromal cells, carry a diverse cargo of proteins, nucleic acids, and lipids...
You really need to initially test your ferritin levels, and then monitor them over time. Additionally, it is often not enough to just eat more iron-rich foods or supplement with iron; many people may also need to address “why” they have iron deficiency in the first place. ...
It may be administered before or after surgery, it may be given alone, or in combination with radiation therapy. It is usually administered in cycles of a few weeks at a time, with a rest period so the body can recover. Side Effects of Pancreatic Cancer Chemotherapy ...
Apoptosis has been established as a mechanism of anti-cancer defense. Members of the BCL-2 family are critical mediators of apoptotic cell death in health and disease, often found to be deregulated in cancer and believed to lead to the survival of malign
many cancer drugs and chemotherapies must be metabolized or activated before they are effective. Giving doses of these therapies when they will be activated at the correct speed will increase the amount of the drug available. Last, chemotherapies work best in the presence of certain hormones. Ho...
Over the past decade, cancer diagnosis has expanded to include liquid biopsies in addition to tissue biopsies. Liquid biopsies can result in earlier and more accurate diagnosis and more effective monitoring of disease progression than tissue biopsies as
A biosimilar is not considered a “generic” in the same way that a traditional, small molecule drug (for example: ibuprofen or acetaminophen) is determined to be a generic. Biosimilars are "similar" because they are biologics that do not have to be exact copies of the active ingredient, as...