However, its success can be limited by the development of acute and chronic graft-versus-host disease (GVHD). Chronic GVHD (cGVHD) is the most common long-term complication following allo-SCT, and patients who develop this condition have significantly higher morbidity and mortality and ...
Finally, particular attention should be paid to signs or symptoms of IPA relapse in the setting of severe acute or chronic GVHD requiring systemic immunosuppression. In that setting, resuming azoles, if previously stopped, would be indicated. In the event of suspicion for IPA relapse, repeat ...
The disadvantage is an increased risk of chronic GvHD in the allogenic HSCT because of an increased number of T cells circulating (Maziarz 2015). 2.3.2 Bone Marrow BM is traditionally harvested from the posterior iliac crests under general or epidural anaesthesia in a surgical room where ...
Hutt increased risk of chronic GvHD in the allogenic HSCT because of an increased number of T cells circulating (Maziarz 2015). 2.3.2 Bone Marrow BM is traditionally harvested from the posterior iliac crests under general or epidural anaesthe- sia in a surgical room where trained haematolo-...
However, ATG has a depletory effect on the (antiviral) T cells in the graft, because of the long half-life of the polyclonal antibodies. Alemtuzumab (Campath-1H; anti-CD52), an alternative to ATG, holds an even higher risk of AdV disease, probably because of deeper in vivo T- and ...
[18]; organ transplantation and the prevention of graft-versus-host disease (GvHD) [19,20,21]; ischemic injuries [22]; diabetes [23]; autoimmune diseases and chronic inflammatory disorders, such as multiple sclerosis; inflammatory bowel diseases and chronic obstructive pulmonary disease (COPD) [...
Although very effective in chronic myeloid leukemia, donor lymphocyte infusion (DLI) has proven to be of limited efficacy in acute leukemia, with less than 25% survival after 2 years [2]. Additionally, complications related to graft-versus-host-disease (GVHD) are responsible for the demise or...