Patients undergoing general surgery [4], oncology patients [5, 6] and those with chronic renal disease [7] are at particular risk of becoming infected during a hospital stay. C. difficile infection can be life-threatening, especially in elderly patients. Because of its long incubation period ...
It is urgent to assess ways to reduce the global spread of bacterial resistance and to select the most effective antibiotic during the initial phase of infection, particularly when resistance affects the most broad-spectrum agents such as carbapenems or, recently, last-line therapies such as β-...
Control of pathogenic bacteria by deliberate application of predatory phages has potential as a powerful therapy against antibiotic-resistant bacteria. The key advantages of phage biocontrol over antibacterial chemotherapy are: (1) an ability to self-propagate inside host bacteria, (2) targeted predation...