A Malaria Fingerprint in the Human Genome ? Reduce , Recycle , Reuse — Iodotyrosine Deiodinase in Thyroid Iodide Metabolism Malaria, a tremendously successful pathogen that is responsible for more than 300 million cases and 1 million deaths annually,1 has had a large impact on the shape of the...
"Reprogramming the way DNA functions is fundamental to all living systems," said Professor Balasubramanian. "It's remarkable that for so long, we weren't aware of these other modifications in human DNA. If we've found four more bases since 2009, then who are we to argue that nothing else...
Local PCA shows how the effect of population structure differs along the genome Population structure leads to systematic patterns in measures of mean relatedness between individuals in large genomic datasets, which are often discovered and visualized using di- mension reduction techniques such as principa...
Although genes get a lot of attention, it’s the proteins that perform most life functions and even make up the majority of cellular structures. Proteins are large, complex molecules made up of smaller subunits called amino acids. Chemical properties that distinguish the 20 different amino acids ...
The nucleotide sequence of the D-loop region of the mitochondrial genome was determined for 45 members of a large matrilineal Leber hereditary optic neuropathy pedigree. Two germ-line mutations have arisen in members of one branch of the family, thereby leading to triplasmic descendants with three...
Size matters: just how big is BIG?: Quantifying realistic sample size requirements for human genome epidemiology. Background Despite earlier doubts, a string of recent successes indicates that if sample sizes are large enough, it is possible-both in theory and in pract......
(PhysOrg.com) -- A gene linked to greater height and later puberty in large population studies shows a true biological effect, according to a new study from Children's Hospital Boston that finds mice with this variant are larger and have delayed sexual m
Here we state the common-sense conclusion, that “such variants do not exist.” Technically: hypotheses about large effect variants have been repeatedly rejected, in large, high-quality studies. Efforts to determine the portions of the genome most likely to harbor GWAS loci are ongoing, and the...
The history of life on Earth is told in the fossil record beneath our feet. However, many fossils abruptly vanish from the record after key dates, indicating that they went extinct because they could no longer adapt to environmental pressures. ...
Then, during the Neolithic Period, around 4,500 years ago, there was a large-scale influx of people from China who introduced farming practices to Southeast Asia and mixed with the local hunter-gatherers. People today with this ancestry mix tend to speak Austroasiatic languages, leading the res...