We examined the association of HDL-C with all-cause and cardiovascular mortality in the Ludwigshafen Risk and Cardiovascular Health study comprising 3307 patients undergoing coronary angiography. Patients were followed for a median of 9.9 years. Estimated GFR (eGFR) was calculated using the Chronic ...
et al. Feedback suppression of PI3Kalpha signaling in PTEN-mutated tumors is relieved by selective inhibition of PI3Kbeta. Cancer Cell 27, 109–122 (2015). Article CAS PubMed Google Scholar Elkabets, M. et al. AXL mediates resistance to PI3Kalpha inhibition by activating the EGFR/PKC/mTOR...
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract disease in young children and elderly people. Although the virus was isolated in 1955, an effective RSV vaccine has not been developed, and the only licensed intervention is passive immunoprophylaxis of high-risk infant...
These equations can be calculated at the bedside or issued by the laboratory and provide accurate GFR estimates from 20 to 60 mL/min/1.73 m2 with good accuracy but moderate to poor bias and precision. Further limiting is the lack of creatinine reference methods and of calibration material. ...
Overall survival is the “gold standard” endpoint in cancer clinical trials. It plays a key role in determining the clinical- and cost-effectiveness of a new intervention and whether it is recommended for use in standard of care. The assessment of overa
This is an important paper clearly showing that eGFR (calculated by standard formulas based on serum creatine or cystatin C) contains information other than true GFR relating to CV risk (see Rule and Lieske [44] for an editorial on the subject). Article Google Scholar Kanbay M, Sanchez-...
This suggests that immune response can be related to the patient's pre- vious treatment, rather than just the expression of PD-L1. Tumor mutation burden Tumor mutation burden (TMB) is another predictor for ICI efficacy (Fig. 1) and is calculated as the total number of nonsynonymous ...
other kinase targets are often calculated by the ratios of their IC50, in which at least 10-fold selectivity is preferred. On the other hand, if a drug candidate has on-target toxicity, which is caused by the inhibition of the disease related target, the solution is limited where titration...
No dose adjustment is required in patients with mild to severe renal impairment (eGFR ≥15 mL/min)1 TRYVIO is not recommended in patients with kidney failure (eGFR <15 mL/min) or on dialysis. Patients with renal impairment are at increased risk of edema and fluid retention. ...
We postulate that a target-centric approach for first-in-class drugs, without consideration of an optimal MMOA, may contribute to the current high attrition rates and low productivity in pharmaceutical research and development. This is a preview of subscription content, access via your institution ...