Protein kinase C (PKC) enzyme family consists of the Ca(2+)-dependent and -independent subgroups of phospholipid/diacylglycerol (DAG)-stimulated serine/threonine protein kinases. These enzymes exhibit distinct cellular and subcellular localizations in CNS and subtle differences in their biochemical ...
The death domain kinase RIP has an essential role in DNA damage-induced NF-κB activation The transcription factor NF-κB is activated when cells are exposed to genotoxic stress. It has been suggested that DNA damage will trigger a cytoplasmic s... MH Gang,J Lewis,Q Yang,... - 《Genes ...
摘要: Human TopBP1 can associate in vitro with a number of DNA templates, although it has yet tobe established whether this binding Claspin and the activated form of ATR-ATRIP collaboratein the activation of Chk1. Identification and functional analysis of TopBP1 and its homologs...
One of these signaling proteins, Akt, is a protein kinase that is activated at the membrane by phosphorylation mediated by two other protein kinases (here called protein kinases 1 and 2); protein kinase 1 is also recruited by the phosphorylated lipid docking sites. D. Once activated, Akt is...
3.3. Ca2+ release activated Ca2+ (CRAC) channels There are different pathways through which calcium can enter the cell to initiate a cascade of intracellular events. One of the main Ca2+ influx routes in cells is represented by store-operated Ca2+ entry (SOCE). SOCE is mediated by a functi...
DNA polymerases were named for their function of catalysing DNA replication, a process that is necessary for growth and propagation of life. DNA involving Watson–Crick base-pairing can be synthesized with high fidelity, the structural and mechanistic origins of which have been investigated for many...
complex,whosecatalysisisgenerallycarriedoutbya heterodimerickinaseconsistingofIKKaandIKKb subunits.Thisreviewdescribestheidenti®cationof proteinsintheIKKcomplex,andtheregulationand physiologicalfunctionsofIKK. Keywords:NF-kB;Rel;IkB;IKK;kinase;phosphor- ...
Protein polyubiquitination occurs through a cascade of enzymatic reactions, the ?rst of which is ATPdependent and is carried out by the E1 ubiquitinactivating enzyme, which forms an E1-ubiquitin thioester. The second reaction is catalyzed by E2 ubiquitin conjugating enzymes, which receive activated ...
In vitro and in vivo phosphorylation and activation assays revealed that Ntf4 shares the same upstream MAPK kinase, NtMEK2, with SIPK and WIPK. Similar to SIPK and WIPK, Ntf4 is also stress responsive and can be activated by cryptogein, a proteinaceous elicitin from oomycetic pathogen ...
A protein related to p21-activated kinase (PAK) that is involved in neurogenesis in the Drosophila adult central nervous system Heisenberg M, Raabe T: A protein related to p21-activated kinase (PAK) that is involved in neurogenesis in the Drosophila adult central nervous system. ... J Melzig...