Reports that a group of researchers has described a mechanism that explains how the tumor suppressor gene P53 is activated in response to DNA damage. How P53 is transported out of the nucleus for degradation during normal cell growth; How kinases that phosphorylate two serine residues at the N-...
The tumour suppressor protein p53 is stabilised and activated in response to ionising radiation. This is known to depend on the kinase ATM; recent results suggest ATM acts via the downstream kinase Chk2/hCds1, which stabilises p53 at least in part by direct phosphorylation of residue serine 20...
Of the many cellular responses activated by TP53, which ones are critical for tumour suppression? Article 08 April 2022 Targeting p53 pathways: mechanisms, structures and advances in therapy Article Open access 01 March 2023 Shifting the paradigms for tumor suppression: lessons from the p53 f...
However, it is still not fully understood which process(es) activated by p53 is/are critical for tumour suppression and how this might differ depending on the type of cells undergoing neoplastic transformation and the nature of the ... Elizabeth,Lieschke,Zilu,... - 《Journal of Molecular Cell...
Jones RG, Plas DR, Kubek S, Buzzai M, Mu J, Xu Y, Birnbaum MJ and Thompson CB (2005) AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol. Cell 18: 283–293. CAS PubMed Google Scholar Livingstone LR, White A, Sprouse J, Livanos E, Jacks T and Tlsty ...
We also consider how mechanisms in addition to phosphorylation by stress-activated kinases can lead to the activation of p53 as a transcription factor, and we review the dual role of p53-activating kinases as tumor suppressors and oncoproteins. Finally, we discuss how changes in the specific ...
We demonstrate that distinct stress-activated kinases, including ataxia telangiectasia mutated (ATM), casein kinase 1 (CK1) and AMP-activated protein kinase (AMPK), mediate phosphorylation of a key phospho-acceptor site in the p53 transactivation domain in response to diverse stresses including ...
27 As such, the delayed sprouting and abnormal branching of the trunk vasculature is unlikely to be a cell autonomous effect, but rather is likely to be secondary to the impairment of somitogenesis. The tissues in which tp53 is activated all display obviously impaired development in the ΔU8-...
The first thing a just activated mitochondria does in a cancer cell is to tell that cell to die. It turns on the apoptosis process of natural cell death because the cancer cell has lived too long. Carbon Transport Elixir energetically tests6600for fighting cancer. Use 1 bottle a month for ...
“I would like to continue to expand our understanding of how p53 is activated in conjunction with PTEN and under what circumstances it functions to protect the cell,” Liu said. Because her work has been done mostly in the test tube, Liu would like to determine whether her findings can b...