Background: Huntington's disease (HD) is a devastating heredoneurodegenerative disorder associated with a wide variety of neurological and psychiatric symptoms caused by an expanded CAG repeat in the HTT gene. The expansion mutation in HTT is dominantly transmitted and codes for a protein named ...
In patients with Huntington's disease, neurons in a part of the brain called the striatum are among the hardest-hit. Degeneration of these neurons contributes to patients' loss of motor control, which is one of the major hallmarks of the disease. Neuroscientists at MIT have now shown that tw...
The discovery of a polymorphic DNA marker for Huntington's Disease (HD) in 1983, and the specific gene responsible in 1993, led to predictive testing programmes out of which came research into whether or not cognitive impairment was present presymptomatically in those at risk for HD. The result...
Huntington disease: How many repeats does it take? 来自 NCBI 喜欢 0 阅读量: 8 作者: Hogarth,P. 摘要: Comment on Neurology. 2013 May 28;80(22):2022-7. 关键词: Humans Huntington Disease Nerve Tissue Proteins Phenotype Trinucleotide Repeat Expansion Male DOI: 10.1212/WNL.0b013e3182984b31...
To evaluate the potential for refinement, as well as its implementation in research, we analysed papers on murine models of Huntington's disease (HD) published between 1999 and 2009 (n = 233). Each study was classified according to a four-level severity scale, in terms of the disease stage...
Understanding quality of life (QoL) is important in diseases for which there is no cure to date, such as Huntington’s disease (HD). A deeper level of understanding is, however, compromised by the lack of studies examining QoL from the perspectives of HD gene expansion carriers (HDGECs). ...
Huntington’s disease Sickle cell anemia Autism Alzheimer’s disease agitation Neuropathies Cachexia and wasting syndrome In a doctor’s professional judgment, any chronic, debilitating, or other medical condition, including hepatitis C In many ways, Missouri residents are fortunate. There were a pair ...
A hallmark of neurodegenerative diseases like Huntington's is the progressive death of nerve cells in the brain. The cells don't die quickly, though. They first start to disconnect from each other because their neurites—long finger-like extensions that make connections all through the brain—bec...
Pruning roses is not as complicated as it may seem, though it’s important to follow the right technique based on the type of rose you have. Here’s how—and when—to prune the roses in your garden! Sure, pruning roses can be a chore, but your efforts will be rewarded by a healthie...
Huntington's disease is a degenerative, hereditary, genetic illness similar to Parkinson's and it affects one in 10,000 in the population. Not only does it destroy the person - mind and body - but it destroys entire families as well. West Belfast journalist SHANE McKAY writes of the havoc...