根据基线重新活检结果分为HER2过表达、HER2低表达和HER2零表达3个队列,队列1纳入72例HER2 IHC 3+或IHC 2+/ISH+,既往接受过紫杉烷类,且对曲妥珠单抗和TDM-1耐药的患者;队列2和队列3分别纳入74例HER2 IHC 2+/ISH-或IHC 1+和40例HER2 IHC 0,且既往接受过蒽环类和紫杉烷类药物治疗的患者;如果是HR+患者,必须...
Jnci Journal of the National Cancer InstituteHow do you tell whether a breast cancer is HER2positive?Ongoing studies keep debate in high gear. Schmidt C. Journal of National Cancer Institute . 2011Schmidt C: How do you tell whether a breast cancer is HER2 positive? Ongoing studies keep debate...
“We've completely flipped the outcomes for HER2-positive breast cancer, where it has gone from one of the most feared types of breast cancer to one of the most successfully treated types of breast cancer.”—Harold Burstein byPeter Attia ...
摘要: Principles of management for patients diagnosed with HER2-positive metastatic breast cancer incorporate patient and tumor parameters including medical condition, prior anti-cancer therapies, and biological tumor characteristics. For the purposes of this discussion...
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He urged hormone-positive breast cancer patients to get treatment at least for five years and up to 10 years. “HER2 is a tumor with unique characteristics. As a result, the patient will have to live with anxiety for a long time,” Lee said. “That’s why patients should know the natu...
2 years versus 1 year of adjuvant trastuzumab for HER2-positive breast cancer (HERA): an open-label, randomised controlled trial. Lancet. 2013;382:1021–8. https://doi.org/10.1016/S0140-6736(13)61094-6. Clinical Trial, Phase III Comparative Study Multicenter Study Randomized Controlled Trial ...
Approximately 15%–30% of breast cancers have overexpression or amplification of human epidermal growth factor receptor 2 (HER2), which is associated
Human epidermal growth factor receptor 2 (HER2) is a protein that can be expressed on the surface of some breast cancer cells.Breast cancerthat expresses HER2 is known asHER2-positiveand HER2-low depending on how many HER2 proteins are on the cells. These types of breast cancer may be able...
were assigned female at birth and were postmenopausal (menopause had already occurred) took Kisqali combined with an aromatase inhibitor hormone therapy called letrozole or a placebo with letrozole for HR-positive, HER2-negative advanced breast cancer that had not been treated for the advanced cancer....