Precisely how BRCA1 inactivation raises cancer risk has remained something of a puzzle. BRCA1 is considered a “tumor suppressor” gene, and typically the loss of one copy of such genes is not enough to cause cancer. That’s because humans inherit two copies of each gene (one from each pa...
Eight categories of metaphors that women used surrounding BRCA gene testing were evident in the data, including those related to (a) knowledge is power; (b) gambling; (c) a journey; (d) a rollercoaster; (e) battle, disaster, or wreckage; (f) Pandoras box or a can of worms; (g) ...
Dr. Anne Peled is a dual-trained breast oncologic and plastic surgeon practicing in San Francisco. She is the co-director of the Sutter Health California Pacific Medical Center Breast Cancer Program. Dr. Peled’s clinical and research interests include oncoplastic surgery, shared decision-making, ...
genetic testing; predictive value; monogenic subtypes; public health INTRODUCTION Background and purpose During the years prior to the turn of the century, scientific and medical attention for genetic disorders was mainly focused on under- standing rare single-gene disorders, such as Huntington's dise...
you can get a pretty good sense of your overall genotype and genetic traits right from the comfort of your home. Of course, for medical purposes or if you have concerns about genetic diseases, it is still best to meet with your doctor or a genetic counselor and have lab testing do...
Stunning advances in gene research and data mining will predict diseases and devise treatments tailored to each of us.
Prevent disease.Once you know you carry a certain gene, you may be able to make lifestyle changes or get medical treatment so you don’t get sick. For example, women who carry the BRCA1 or BRCA2 gene mutation are at higher risk forbreast cancer. To lower their risk, they may choose...
You may be at higher risk for many reasons, including a family history of breast cancer, a genetic mutation that can increase your risk (such as the BRCA1, BRCA2, or PALB2 gene), or a history of chest radiation therapy before age 30. Why do dense breasts matter when having a ...
Studies suggest that adiposity in childhood may reduce the risk of breast cancer in later life. The biological mechanism underlying this effect is unclear but is likely to be independent of body size in adulthood. Using a Mendelian randomization framewor
PARP inhibitors are a type of targeted cancer drug that have caused a breakthrough in cancer treatment over the last few decades, in part following the discovery of the breast cancer susceptibility gene, BRCA2 by ICR scientists in 1995. ...