The structure shows CoA in a syn conformation awaiting pyruvate cleavage. By changing to an anti conformation, without affecting the adenine binding mode of CoA, the thiol of CoA could pick up the acetyl group resulting from pyruvate cleavage....
Amino acids that are degraded to pyruvate, α-ketoglutarate, succinyl CoA, fumarate, or oxaloacetate are termedglucogenic amino acids. ... Some of their carbon atoms emerge in acetyl CoA or acetoacetyl CoA, whereas others appear in potential precursors of glucose. The other 14 amino acids are ...
In the propionate branch of the pathway, 2 NADH molecules are oxidized to 2 NAD1; during reduction of pyruvate to acetate, an extra ATP is generated from ADP when acetyl phosphate is converted to acetate, before which acetyl-CoA is converted to acetyl phosphate as the previous step12. NADH...
Calculate the net ATP molecules generated (include ATP generated from oxidation of all cofactors) when 1 molecule of fructose-6-phosphate is converted into 2 acetyl-CoA molecules. Assume the glycerol-3-phosphate shuttle is used. How many ATP are obtained by substrate-level...
How much ATP energy would you get from a tripeptide that, upon hydrolysis and deamination, makes two acetyl CoA and one pyruvate molecule and undergo aerobic respiration? How many ATP molecules must be used to break down 2 glucose molecules in the energy consuming phase of ...
How many NADH and FADH2 are formed from each original pyruvate molecule in each "Turn" of the Kreb's cycle? What is the ATP yield per glucose molecule in process of glycolysis plus the common metabolic pathway? How much ATP will be produced based only on the number of Acetyl-...
Proteins were detected using primary antibodies at a 1:1000 dilution: phospho-AMPK (Thr-172), phospho-acetyl-CoA carboxylase (phospho-ACC), phospho-eIF2α, phospho-GSK3β (Cell Signaling), phospho-ERK (anti-active MAPK polyclonal antibody), phospho-p38 (Promega, Madison, WI), PAR (Trevigen...
pyruvate, carbon dioxide is released, and the high-energy molecule NADH is formed.Flavin adenine dinucleotide(FAD) works in much the same way, becoming FADH2. The product of the overall reaction isacetyl coenzyme A(acetyl CoA), which is a carbohydrate molecule that puts the Krebs cycle in ...
The citric acid cycle is part of aerobic respiration, but no oxygen is required for the cycle. Explain this paradox. What does the Krebs cycle produce? Citric Acid Cycle A. 34 ATP B. 2 ATP Why must pyruvate be converted to Acetyl CoA before entering the Citric Acid Cycle? ...
Why is pyruvate reduced during fermentation and not cellular respiration? Why does oxaloacetate need to leave the mitochondria to go through with gluconeogenesis? How does the catabolism of glucose contribute to ATP synthesis? Why is acetyl-CoA not used in gluconeogenesis? Why is NADH converted to ...