The formation of membrane contact sites between cellular organelles is required for proper organelle communication and maintenance in the compartmentalized eukaryotic cell. We recently identified a tether that links peroxisomes to the cortical ER in the yeast, Saccharomyces cerevisiae. The tether is made ...
Eukaryotic cells are subcompartmentalized into discrete, membrane-enclosed organelles. These organelles must be preserved in cells over many generations to maintain the selective advantages afforded by compartmentalization. Cells use complex molecular mechanisms of organelle inheritance to achieve high accuracy ...
There is also evidence that enzymes may be assembled into much larger hyperstructures [8], as in the case of cellulolytic enzymes in bacteria such as Acetivibrio cellulolyticus [9] or compartmentalized into organelles such as glycosomes as in the case of glycolytic enzymes in trypanosomes [10]...
ion channel; membrane potential; tumor immunity; pH homeostasis; protonation; cancer physiology; tumor microenvironment; cell adhesion molecules Graphical Abstract 1. Introduction The acidification of the tumor microenvironment (TME) is a prominent environmental driver of cancer progression. One major cause...
The 26S proteasome is a complex oligomeric structure that is present in both the cytoplasm and the nucleus of eukaryotic cells. The 26S proteasome is an ATP dependent protease composed of the 20S, which contains the proteolytic active sites, and the 19S regulatory particle [111]. The 19S ...