Acute infusion reactions are common and can be handled easily, whereas the major concerns regarding rituximab include an increased risk of infection due to chronic B cell depletion, hypogammaglobulinemia, late-onset neutropenia, and the extremely rare progressive multifocal leukoencephalopathy. Importantly...
In the vignettes described here, Patient 1 should be diagnosed with constitutional/ethnic neutropenia and not be subjected to further workup. Extensive evaluation of a healthy patient of African descent with an ANC in this range, even in the absence of a past history of CBC panels, is ...
Can I work during chemo? Chemo affects everyone differently. It’s hard to know how you’ll feel ahead of time, but your doctor can give you an idea of what you can expect. Some people might be able to continue their daily activities, but others might need to take time off work. You...
physical examination, complete blood count, and peripheral blood film assessment are the basic workups for suspected patients. Splenomegaly and constitutional symptoms (e.g., fever, weight loss, or lymphadenopathy) are unusual and, if present, should be investigated further ...
A diagnostic workup revealed an AML with myelodysplasia-related changes. The bone marrow was hypocellular, with 20% blasts; cytogenetic analysis showed a complex karyotype; and molecular screening revealed mutations in TP53, DNMT3A, and NRAS. The patient had an ECOG (Eastern Cooperative Oncology ...
Leukopenia is so often caused from adecrease in neutrophilsthat some people use the terms “leukopenia” and “neutropenia” interchangeably. Another common type of leukopenia is lymphocytopenia, which is when you have too few lymphocytes. Lymphocytes are the white blood cells that protect you from...
Neutropenia occurs when the absolute neutrophil count is <500 cells/mm3. After the chemotherapy, the blood count decreases and the duration of neutropenic phase varies according to several factors, such as source of cells, type of transplantation, conditioning regimen, and will influence both short-...
albicans Prolonged ICU stay, Corticosteroids, prolonged antimicrobial use, chemotherapy, immunosuppressive agents, Diabetes mellitus, Advanced age, Central venous catheter, Gastrointestinal surgery, Total parenteral nutrition, Pancreatitis, Neutropenia, High disease severity score (APACHE II > 20), Renal ...
Jean Klastersky traced the history of supportive care from initial chemotherapy for acute myeloid leukemia, where supportive care predominantly involved blood products and management of febrile neutropenia, through to the advent of cisplatin for solid tumors in which control of nausea and vomiting ...
However, 41% of participants experienced grade 3 to 4 neutropenia, and infections were frequent. A later follow-up study seems to confirm a suspected risk of late-occurring malignancies but also shows a median response duration of 77 months and a 5-year continued response rate in 71% of ...