In addition to the nucleus and mitochondria, other major cellular organelles include the Golgi apparatus, which modifies and transports proteins. It is often referred to as the "post office" of cells. The endoplasmic reticulum is another organelle. It's involved in the synthesis, folding and tran...
and how Rab/Ypt proteins regulate the vesicle predocking events, it is discussed how these proteins might participate in the events that lead to vesicle movement through association with the cytoskeleton machinery.
NLRP3 cellular localization. The cellular localization of NLRP3 has a significant impact on its activity and effector function. NLRP3 has been found in close proximity to mitochondria, the endoplasmic reticulum, and the Golgi apparatus. Changes to and within these organelles can directly contribute t...
(aa 116–125) that conferred stability to the TAP inter- action and enhanced the inhibitory effect.90 Other HCMV regulated functions that might affect classical MHC I molecules in HCMV-infected cells It is conceivable that in addition to US2, US3, US6 and US11, additional proteins impact ...
UL142 is a MHC I-like protein that inhibits the expression of MICA and ULBP3.135,136Similar to UL16, UL142-targeted proteins are not degraded but retained in an intracellular compartment, in this case, in the ER and cis-Golgi (Figure 3).135,136It was shown that the TMS of UL142 is...
Proteins with ALPS motifs often localize at membranes with low content of negatively charged lipids, like the ER network and the cis-Golgi apparatus, and thus rely mainly on hydrophobic interactions to partition into the bilayer. In the case of Nup133, the ALPS motif loops out from the N-...
The interpretation of all this data in the sense of fully understanding how glycosylation modifies the immune response against MUC1 or even other proteins would lead to the development of a MUC1-based cancer vaccine that consistently elicits relevant humoral and cellular immunity that has not yet ...
Finally, it was also demonstrated that the crosstalk between RTKs subunits and other lipid rafts associated proteins is also regulated by gangliosides. Figure 2. Regulation of RTKs activation by gangliosides. RTKs common structure consists in an extracellular domain containing the ligand binding site...