“Although it has been nearly 20 years since the human genome was sequenced, how this genomic information is selectively utilized to direct patterns of gene expression underpinning cell fate decisions still remains poorly understood,” Tremethick said. “While there is still much work to ...
Thus far, the genetic mutations harbored by BCL-2 family proteins are uncommon (more indeed will be discovered when more cancer genomes are sequenced), but other chromosomal abnormalities exist, which can lead to the upregulation of BCL2 family proteins. For instance, the amplification of MCL-...
We applied our method to a set of 32 publicly available RNA-seq experiments, including the evaluation of 311 individually sequenced libraries. We found that in the majority of the cases more than one thousand genes are undetected, and that on average approximately 6% of the expressed genes per...
Metagenomicsinvolves obtaining DNA from all microorganisms within a community, without necessarily identifying all of the species involved. After the genes are sequenced and compared with identified sequences, the functions of these genes can be determined. What technique is used in metagenomics? A samp...
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Researchers added 200 million DNA base pairs and 115 protein-coding genes — but they’ve yet to entirely sequence the Y chromosome. By Sara Reardon Twitter Facebook Email When the sequencing of the human genome was announced two decades ago by the Human Genome Project and biotech firm Celera...
The team found that 13 of the 17 species carried laterally transferred genes – indicating widespread transfer. In total 170 genes had been transferred. “As more and more genomes of eukaryotes are sequenced, we’re seeing so many examples of horizontal gene transfer,” says Jul...
double-stranded DNA libraries. Subsequently, the transcriptomic data are sequenced using NGS platforms, and the information is assigned to individual cells. By clustering cells based on similarities in gene expression profiles, cell types can be annotated using known marker genes. Additionally, cells ...
You’ve sequenced genomes of very long-lived animals such as the bowhead whale, which lives up to 200 years. How are their genes different from ours, and what can we learn from them? Various long-lived animals, such as humans, whales and elephants, all have to cope with the same issue...
The discovery is significant, as it represents one of the most common single-gene genetic causes of such disorders, ranking second only to Rett syndrome among patients sequenced by the United Kingdom’s Genomic Medicine Service. Notably, these mutations are typically spontaneous and not inherited, ...