WorksSex chromosome structureThe X chromosomeThe Y chromosomeX inactivationTake-Away Message#Gene StructureIntrons and exons#Introns and exons#Regulating Gene ExpressionGene promotersAlternative splicing & protein isoformsDistal regulatory elementsLocus control regions#Gene promoters#Alternative splicing & protein...
The trick, then, is in getting the new gene into the bacteria. The easiest way is to splice the gene into aplasmid-- a small ring of DNA that bacteria often pass to one another in a primitive form of sex. Scientists have developed very precise tools for cutting standard plasmids and s...
Gene splicing Human genome Genetic engineering Recombinant DNA Genetic diseases Gene therapy DNA mutations DNA fingerprinting or DNA profiling Gene science and genetics are rapidly changing the face of medicine, agriculture and even the legal system! In this article, we'll delve down to the molec...
Last month saw the first-ever approval of a gene therapy that uses the CRISPR–Cas9 gene-editing tool, a treatment for the blood conditions sickle-cell disease and β-thalassaemia that works by precisely cutting out a faulty gene in people’s stem cells....
In this article, I review the results of studies on the origin of life distinct from the popular RNA world hypothesis. The alternate scenario postulates the origin of the first bimolecular genetic system (a polynucleotide gene and a polypeptide processiv
Loss of PRMT5’s methylation function leads to defects in RNA splicing, gene expression and genome integrity, eventually leading to cancer cell death. PRMT5-based synthetic lethality has the potential to be useful in a variety of tumour types including breast, lung and gastric cancers and B cel...
Initial works have been done using small molecules to activate or inhibit (hopefully) single cellular functions. Later on, gene augmentation or elimination has been the focus of much of cell biology, as well as transgenic and knockout (KO) models, for the last two decades. With ...
Transcription is complicated by extensive overlap of transcriptional units as well as alternative initiation, splicing and termination; this complex transcriptional organization challenges the traditional definition of a "gene", suggesting that transcripts should be used as operational units of genomes [44]...
Functions for navigating the Gene Transfer Format (GTF) hierarchy to assist with alternative gene splicing and isoform analyses The following functions of the GTFAnnotation class help you navigate the GTF information hierarchy to perform alternative gene splicing and isoform analyses: • getSegments ...
This powerful nuclease was also used toinvestigate the role of the myostatin gene in muscular atrophy and sarcopenia. The pre-clinical study found that SaCas9-mediated knockout of the myostatin gene in a mouse model resulted in an increase in body weight, improved muscle cell differentiation, and...