It is composed of a simple linear aliphatic polyester and forms a crystalline or semicrystalline polymer with very good physicochemical properties, such as fast degradation, good barrier properties, high tensile modulus (12.5 GPa), moderate melting point (Tm) > 200 °C, and a glass transition ...
In situ single cell observation by fluorescence resonance energy transfer reveals fast intra-cytoplasmic delivery and easy release of plasmid DNA complexed with linear polyethylenimine. J. Gene Med. 2004, 6, 76–84. [CrossRef] [PubMed] 207. Grandinetti, G.; Ingle, N.P.; Reineke, T.M. ...
Studies showed that plasmids, compared to other administration forms like minicircles, are degraded relatively fast within one week [48]. DNA molecules that successfully enter the cell need to pass the barrier of the nuclear membrane to be transcribed [11]. Hence, due to the low amount of ...