The main goal of a case-series study is to generate hypotheses that can be further validated by rigorous statistical methods. Conclusions and perspectives The effective use of the SEER database for cancer research depends on the appropriate application of study designs and statistical models. The ...
Jeffrey L, Probstfield. How cost-effective are new preventive strategies for cardiovascular disease? Am J Cardiol. 2003; 91: 22-7.Probstfield JL. How cost-effective are new preventive strategies for cardiovascular disease? Am J CardioI. 2003; 91 (Suppl):22G–7G....
What Makes the Polypill Effective? One explanation behind the effectiveness of the polypill is the convenience people felt taking one pill instead of multiple drugs. The study found that people were more likely to adhere to the treatment—taking it as directed and refilling it as needed—when tak...
Amiodarone has proven to be effective for suppressing ventricular arrhythmias, reducing sudden death and cardiac mortality, and improving exercise tolerance and ejection fraction. This drug can accumulate in the liver, but no dosage reduction is indicated in cases of hepatic impairment. However, amiodaro...
Nevertheless, drug forgiveness is difficult to quantify and compare between different drugs. In this paper, we construct and analyze a stochastic pharmacokinetic/pharmacodynamic (PK/PD) model to quantify and understand drug forgiveness. The model parameterizes a medication merely by an effective rate ...
Inhibition of the renin–angiotensin–aldosterone system (RAAS) reduces the rate of progression of cardiovascular and renal disease in patients with established cardiac or renal dysfunction. The RAAS is complex with both autocrine, paracrine, and endocrine effects and there are multiple locations in thi...
RE are also routinely incorporated into health economic assessments but it is unknown if the cost-effectiveness results vary according to the RE applied. PURPOSE. To determine the cost-effectiveness of a CV polypill (ASA 100mg, atorvastatin 20/40mg and ramipril 2.5/5/10mg) strategy compared to ...
It is still not known whether more effective angiotensin II blockade will provide more complete LVH reversal, improve cardiac function, prevent damage to other target organs and enhance prognosis. To find the answer, The ONgoing Telmisartan Alone and in combination with Ramipril GLobal Endpoint Trial...
RamiprilCandesartanTelmisartanAliskirenAngiotensin-converting enzyme inhibitors (ACE-Is) and 尾-adrenergic receptor blockers (BBs) have been effective in reducing cardiovascular morbidity and mortality in patients with heart failure (HF) and left ventricular systolic dysfunction (LVSD). Angiotensin receptor ...