Single-cell RNAseq and alternative splicing studies have recently become two of the most prominent applications of RNAseq. However, the combination of both is still challenging, and few research efforts have bee
How does RNA decompose in the cell? How are RNA genomes replicated? What if all the DNA turned into RNA? How is mRNA synthesized from DNA? How is DNA different from RNA? Where in the cell is RNA made? How are DNA, RNA, and proteins related in the cell?
How deep is enough in single-cell RNA-seq? Nat Biotechnol. 2014; 32 (10):1005-6. doi: 10.1038/nbt.3039 PMID: 25299920Streets AM, Huang Y (2014) How deep is enough in single-cell RNA- seq? Nat Biotechnol 32(10):1005-1006Streets AM, Huang YY. How deep is enough in single-cell ...
The first proposes that the viral RNA contains specific sequences or “packaging signals” that enable it to be recognised from a mixture of RNAs within an infected cell. The second suggests that there is a functional coupling between RNA replication and packaging that leads to only replicating,...
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How an RNA virus could insert DNA copies into a host's cell? How can it have DNA as an RNA virus? Explain. What is the role of RNA? How does protein synthesis differ between prokaryotes and eukaryotes? Is the difference between RNA and DNA that the RNA duplicates itself in the cytoplas...
explicit regulation there are also new appreciations for the role of RNA conformational switching in the activation of the spliceosome,28 the assembly of the ribosome,29, 30 and as we later speculate for heterogeneous nuclear RNA proteins, in guiding dynamic RNA folding pathways in the cell. Even...
As the cell cannot allow an indiscriminate ssDNA degradationunleashed. The answer to these problems can be found in the bacterial genomesencoding Cas12a. Use of a conserved sequence of the crRNA for a database searchdisclosed that different bacteria encode a single copy of the Cas12a gene,whereas...
The guide RNA is paired with a Cas9 enzyme to make edits in the genome. Once the RNA binds to the desired sequence, the enzyme swoops in and cuts both strands of DNA. In response, the cell attempts to glue the strands back together, but it uses afault-ridden processthat often introduce...
DNA polymerases were named for their function of catalysing DNA replication, a process that is necessary for growth and propagation of life. DNA involving Watson–Crick base-pairing can be synthesized with high fidelity, the structural and mechanistic or