RNA structure and functionCold Spring Harbor Laboratory Press It is well established that RNA structure is essential for the function of ribosomal, transfer, spliceosomal and catalytic RNAs. Although studying th
conformational switching strand displacement cotranscriptional RNA folding protein-mediated RNA folding Introduction RNA function has long been known to be deeply intertwined with RNA structure.1 Recently, progress in high resolution static structural determination from x-ray crystallography,2 NMR,3 and cryo...
Learn the difference between DNA and RNA, learn about the 3 types of RNA and their functions and understand the structure and function of mRNA, tRNA and rRNA. Related to this Question How does RNA differ from DNA in structure? How does RNA structure differ from DNA structure?
How did RNA and DNA end up together in living things? Can you explain the DNA-RNA-PROTEIN concept? How do you know what the template strand is for mRNA? Summarize how DNA and RNA differ in structure and function. What is the role of RNA and how does it differ from DNA?
Genetic studies in yeast indicate that RNA transcripts facilitate homology-directed DNA repair in a manner that is dependent on RAD52. The molecular basis for so-called RNA−DNA repair, however, remains unknown. Using reconstitution assays, we demonstr
Conservation of lncRNA expression can also be indicative of conservation of regulatory regions, such as transcription factor binding sites within promoters [117]. However, conservation of expression does not necessarily mean the RNA product is important for lncRNA function. Enhancer RNAs (eRNAs), for...
How does CRISPR edit DNA? Researchers have taken advantage of the CRISPR system's ability to make precise cuts in DNA. Byadapting CRISPR to make desirable genome editsin any cell type, researchers can alter genes or DNA sequences that regulate genes' activity, changing their function or express...
Functional complexity.Because the new modalities are complex, with a potentially huge solution space, it is challenging to establish an accurate relationship between the sequence (DNA, RNA, or amino acid), its structural properties, and observed functional behaviors—ultimately, connecting the d...
A new technique has the potential to change the foods we eat every day, boosting flavor, disease resistance, and yields, and even tackling allergens like gluten—and scientists say they're working only with nature's own tools.
More recently, the RNA-based CRISPR gene-editing technology has been developed, which involves using a Cas9 endonuclease targeted to the desired site by a short piece of RNA (sgRNA) The protein engineering required to reprogram ZFNs and TALENs can be time consuming, challenging, and costly...