Neprilysin degrades vasoactive peptides including natriuretic peptides and bradykinin. Inhibition of neprilysin helps to counteract the detrimental effects of neurohormonal overactivation in chronic heart failure that leads to vasoconstriction, sodium retention, and remodeling. With the PARADIGM-HF trial in ...
Besides, atorvastatin (an inhibitor of β-Hydroxy β-methylglutaryl-CoA or HMG-CoA reductase), chloroquine and clarithromycin (an antibiotic), losartan and telmisartan (AT1R inhibitor), sacubitril/valsartan (an angiotensin receptor-neprilysin inhibitor), IFN-β and IFN-γ, nitazoxanide (a thiazolide...
neprilysin; IDE, insulin-degrading enzyme; BBB, blood–brain barrier; LRP-1, lipoprotein receptor-related protein-1; RAGE, receptor for advanced glycation end; MAPT, microtubule-associated protein tau; GSK3β, glycogen synthase kinase 3 beta; CR, Congo Red; ThT, thioflavin T; ANS, 1-anilino...