"Any risk of safety has to be really understood before we start. For therapy, (mRNA) needs to be administered on a chronic basis." The template for mRNA protein synthesis can lead to loss of some protein function, known as RNA toxicity. The fatty envelope of lipid nanoparticles that delive...
How is RNA therapy given? Why do retroviruses contain two identical RNA molecules? How do viruses get their DNA or RNA? How does RNA polymerase generate RNA without a primer? Why does DNA have to turn into RNA before it can make a protein? Why can't DNA just make the proteins itself?
“The first versions of mRNA therapeutics, like the Covid-19 vaccines, just recapitulate how our body’s natural mRNAs work,” Becraft explains. “Natural mRNAs last for a few days, maybe less, and they express a single protein. They have no context-dependent actions. That means wherever t...
nearly 80 percent of their antibodies targeted a fourth part of the receptor-binding domain, or other epitopes altogether. The authors concluded that feedback inhibition was at work—after monoclonal antibody therapy led to the production
scientist, generate obvious “But what if..?” questions that could be asked of experts to check for themselves whether the pushers of the “vaccines” would personally vouch for their safety. For example, the CDC put out an infographic that stated the following.“How does the vaccine work?
World Health Organization now recommends that HIV-positive mothers continue to breastfeed their babies because of breast milk's overwhelming health benefits. WHO does recommend, however, that both the mother and the baby take antiretroviral therapy to help reduce the risk of transmission [source:WHO...
Pfizer has recently announced that it is ready with a Covid-19 vaccine that is 90 percent effective. The vaccine is a so-called mRNA vaccine that has been developed jointly by Pfizer and BioNTech. But what is mRNA technology, and how does it work?
WHO does recommend, however, that both the mother and the baby take antiretroviral therapy to help reduce the risk of transmission [source: WHO]. A fragile virus that can't survive outside the human body, HIV does not transmit through the air. It also can't be contracted like a cold ...
How does alternate splicing work? In alternative splicing,interactions between different proteins, the cell, and the environment can cause different segments of the original DNA to be omitted from the mRNA. When this happens, the alternate mRNA is translated into an entirely different protein. ...
However, the B cells in the tertiary lymphoid structure (TLS) are related to the bet- ter treatment response of immunotherapy and provide a new tool for the prognosis prediction of tumor immu- notherapy [66]. The TLS in patients with NSCLC char- acterized by clusters of mature dendritic ...