aChronic insulin exposure of Hep G2 cells induces the downregulation of insulin signal transduction via PI3K pathway. The effect of metformin on insulin signaling transduction represent a primary mechanism of metformin action in insulin resistant state. 酷G2细胞慢性胰岛素曝光通过PI3K路导致胰岛素信号转导...
These data support a novel mechanism involving PKA-dependent AMPK phosphorylation that provides new insight into how glucagon and metformin modulate hepatic insulin r 相反, metformin减少PKA活动,导致减少的pAMPKSer173和增加的pAMPKThr172,造成AKT的增加的磷酸化。 这数据支持介入提供新的洞察入的PKA依赖AMPK...
How does Viagra do that? And why does Viagra work only if the man is sexually stimulated? For that matter, what causes an erection in the first place? In this article, we'll answer all of those questions and more. This is a fascinating story -- it involves the technology of the human...
But in truth it was God that gave me the cure as a result of a lot of prayer a lot of courage and a lot of recklessness and a lot of research and a lot of careful meticulous testing with a continuous glucose monitor in collaboration with my good friend and ex boss Brian Bain, my ...
Medication nonadherence is one of the largest problems in healthcare today, particularly for patients undergoing long-term pharmacotherapy. To combat nonad
Over the last two decades, the understanding of how dysregulated ion channels and transporters are involved in carcinogenesis and tumor growth and progression, including invasiveness and metastasis, has been increasing exponentially. The present review s
Currently, a very few studies have been conducted on metformin in association with COVID-19 in vitro and therefore, the exact mechanism of action is unknown. However, a few possible mechanisms of action have been reported [125,126]. Darunavir is a potent HIV protease inhibitor [112]. ...
Based on a widely recognized potential mechanism of the Warburg effect, we here summarized the relationship between DNA methylation and the Warburg effect with regard to cellular energy metabolism factors, such as glycolysis related enzymes, mitochondrial function, glycolysis bypass pathways, the tumor ...
Similarly, a possible mechanism of SARS-CoV- 2-mediated inflammatory responses consists of downregula- tion and shedding of ACE2, a terminal carboxypeptidase that degrades angiotensin II to angiotensin (1–7), thus acting as a negative regulator of the renin-angiotensin system [35]. While ACE,...
In recent years, the RNA molecule became one of the most promising targets for therapeutic intervention. Currently, a large number of RNA-based therapeutics are being investigated both at the basic research level and in late-stage clinical trials. Some o