Splenomegaly and constitutional symptoms (e.g., fever, weight loss, or lymphadenopathy) are unusual and, if present, should be investigated further to exclude the presence of other underlying diseases. Several additional tests, including reticulocyte counts, quantitative immunoglobulin (Ig) levels, ...
Additional findings may help doctors narrow the cause. Accumulation of fluid in the abdomen (ascites), an enlarged spleen (splenomegaly), and yellow color of the skin and/or eyes (jaundice) suggest bleeding caused by liver disease. A woman who is pregnant or has recently delivered or a person...
family history, and personal history of cancers, drug and alcohol use, bleeding problems, and other medical conditions (rheumatic diseases, liver problems,kidney disease) needs to be included in this evaluation. Anenlarged spleen(splenomegaly)
How does hemolytic anemia affect the liver function? In hemolytic anemia,jaundice and hepatosplenomegalyare often seen mimicking liver diseases. In hematologic malignancies, malignant cells often infiltrate the liver and may demonstrate abnormal liver function test results accompanied by hepatosplenomegaly or...
Heart failure can cause acute or chronic liver injury due to ischaemia and passive venous congestion, respectively. Congestive hepatopathy is frequently observed in patients with congenital heart disease and after the Fontan procedure, but also in older patients with chronic heart failure. As congestive...
These include the age of the patient and possible comorbidity, the presence of cytopenias, especially thrombocytopenia, the presence of symptoms and signs indicative of hyperviscosity, the need for rapid disease control due to severe symptoms, significant splenomegaly or lymphadenopathy, symptomatic ...
Furthermore, HLH seldom occurs in IBD,39 whereas isolated splenomegaly is unrelated to Crohn disease. Table 2 indicates that disease presentation is quite variable, even for mem- bers of the same family carrying the same XIAP mutation. A recent study in a Japanese cohort of 17 children with ...
Typhoid is a bacterial disease. The bacteria live in the bloodstream when this infected blood reaches the brain it will affect the brain and cause meningitis. But if it is treated early this situation can be avoided. Does Typhoid Cause Muscle Pain? Yes, muscle pain is one of the typhoid sy...
notably disease-relevant CD11c + age-associated B cells [115,116] Splenomegaly was observed in theFtx-/- model, and signs of glomerulonephritis were found in the B cell-specificXistKO. These results link a reduction ofXistexpression in one or more immune cell types and the development of...
ITP remains a diagnosis of exclusion due to the lack of a “gold standard” diagnostic test. History taking, physical examination, complete blood count, and peripheral blood film assessment are the basic workups for suspected patients. Splenomegaly and constitutional symptoms (e.g., fever, weight...