A new study reveals that nuclear deformation is sufficient to trigger double-strand breaks at sites of active DNA replication.doi:10.1016/j.cub.2020.12.022Ryan J. PetrieCurrent Biology
Why does DNA damage lead to autoimmunity? How do single-stranded DNA viruses replicate? What do DNA repair genes do? What are DNA repair genes? What could be the result of damaged DNA being replicated? How stable is single-stranded DNA?
The future is not bright for a cell with DNA damage. Usually, the DNA that is damaged is in an unused portion of the genome. However, damage a vital part of the genome, and the outlook turns grim, because this DNA damage leads to one of four fates for the stricken cell: 1) suicide...
We're learning more about the craving that fuels self-defeating habits—and how new discoveries can help us kick the habit.
DNA polymerases were named for their function of catalysing DNA replication, a process that is necessary for growth and propagation of life. DNA involving Watson–Crick base-pairing can be synthesized with high fidelity, the structural and mechanistic origins of which have been investigated for many...
A person's head has 100,000 hair follicles, and when any of them shut down or gets severely damaged, that's it. No new follicles are going to appear, and follicles are limited in their ability to regenerate. However, researchers at the University of Pennsylvania, led by Dr. George...
Does DNA damage, is that affecting the telomeres?Rowena: You know, that’s not my area of expertise and it certainly would, but that’s a key aspect of it. But the telomeres per se are not something we’ve studied directly. We have looked at double strand DNA breaks, which are the ...
Why are there sometimes errors as DNA copies itself during cell division which causes mutation? Explain the process of DNA replication including how strands are separated, the enzymes involved, and how the DNA template works to identify and repair errors. Where does DNA replication take place? Whe...
When cell death has been triggered by extrinsic factors such as TNFa, ceramide or Fas-receptor ligation, ROCK1 cleavage and activation are relatively late events,6,7 consequently ROCK inhibition does not halt the apoptotic process.6 However, in some contexts chronic or high-intensity ROCK activity...
The genus Enterovirus (EV) of the family Picornaviridae includes poliovirus, coxsackieviruses, echoviruses, numbered enteroviruses and rhinoviruses. These diverse viruses cause a variety of diseases, including non-specific febrile illness, hand-foot-and-