elastase [162], collagenase [163], and MMPs secretion are increased in AA [164]. The main components of ECM, fibronectin, laminin, collagen, and elastin was connected to VSMCs by integrin-based focal adhesions and transferred anchorage and traction forces, providing structural support [165,166,...
Matrix metalloproteinases are classified according to their function as collagenases, gelatinases, stromelysins, matrilysins, enamelysins, membrane-type MMPs, and others. Matrix metalloproteinases are pH- and temperature-dependent for their efficacy and stability. MMP1, classified as Collagenase is one ...
in cellular targets of rheumatoid arthritis in vitro and demonstrated the compound abolished the p65 NF-κB nuclear translocation as well as binding activity of NF-κB DNA in the PMA-stimulated synovial fibroblasts via inhibited COX-2, IL-6, MMP-3, collagenase and pro-gelatinase B(pro-MMP-9)...
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Recent studies using a miniprocollagen III substrate have shown that enhancing activity is unaffected by removal of essentially all of the triple-helical region using highly purified bacterial collagenase (28). Taken together, these data suggest that PCPE-1 binds to the non-triple-helical ...
aintracerebral injection of thrombin was performed in an identical fashion to injection of collagenase ,except that 5U of rat thrombin,in 5uL oxygen-free normal saline was injected at a rate of 1 uL per minute. 凝血酶的大脑内射入在相同时尚进行了对胶原酶的射入,除了鼠凝血酶5U,在5uL氧气畅通...
Spleens harvested from euthanized mice were minced with scissors in RP-2.5 (2.5% FBS) containing collagenase VIII (1 mg/ml, Sigma) and DNase (10 μg/ml, Sigma). Minced tissues were incubated at 37°C for 45 min with gentle agitation. After straining digested tissues, single-cell suspensi...
The Effects of Intra-Articular Platelet-Rich Plasma Injection According to the Severity of Collagenase-Induced Knee Osteoarthritis in a Rabbit Model to normal ambulation without the non-weight bearing lameness of the affected limb were recorded, and the lameness periods were calculated for each group....
elastase [162], collagenase [163], and MMPs secretion are increased in AA [164]. The main components of ECM, fibronectin, laminin, collagen, and elastin was connected to VSMCs by integrin-based focal adhesions and transferred anchorage and traction forces, providing structural support [165,166...
Rheumatoid arthritis does not kill quickly but today it looks like a sentence to a hard-to-treat disease. This, coupled with the many different factors that can trigger RA, may explain why this disease is not treated successfully, with continued high incidence. Now the range of drugs is exte...