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Subpopulations of soluble, misfolded proteins can bypass chaperones within cells. The extent of this phenomenon and how it happens at the molecular level are unknown. Through a meta-analysis of the experimental literature we find that in all quantitative protein refolding studies there is always a s...
partly by direct training, partly by letting it find out things for itself. We don’t know how to do this yet, but I believe that it will be achieved in the very near future—and
such technology could become useful in the early diagnosis of diseases, maybe even before the clinical onset, allowing a clinical monitoring of disease progression and helping in performing the best therapeutic approach, potentially predicting the therapy response and avoiding overtreatments. Moreover, th...
Question: How is changing the concentration of a reactant in a reaction related to a shift in equilibrium position? Le Chatelier's Principle: Le Chatelier's Principle states that when a reaction system at equilibrium is disturbed, it may shift left or r...
The development of new drugs will certainly benefit from an ever improving knowledge of the living beings chemistry. However, identification of drugable molecules within the immense biodiversity of forests, soils or oceans still requires considerable investments in technical equipments, time and human reso...
The Cerrado—an edaphic type of savannah— comprises the second largest biome of the Brazilian territory and is the main area for grain production in the country, but information about the impact of land conversion to agriculture on microbial diversity i
However, by reviewing the mechanisms of liver protection and hepatotoxicity, it is not difficult to find that anthraquinones in Rhubarb have bidirectional dose-protection/toxicity effects. It was found that medium dose (5.4 g/kg) of Rhubarb had a therapeutic effect on liver injury model rats, ...
(FIND), the WHO and the Centers for Disease Control and Prevention, 293 malaria RDTs were evaluated from 2008 to 2016 [31]. Most of the evaluated malaria RDTs detectP. falciparumhistidine-rich protein 2 (PfHRP2) orP. falciparumlactase dehydrogenase (PfpLDH). In the last round of ...
You would, I believe, probably, find a college student who has no idea about how many letters in the English alphabet before you find a student who is not in possession of a smartphone, which almost everyone around me carries with 24 hours a day. Indeed, smartphone seems to be useful ...