Moreover, it is clear that though some of the mutant Ph-positive subclones that develop in patients taking tyrosine kinase inhibitors (TKIs) are the direct cause of the resistance observed, in other cases, its cause is unclear. It is likely that in the next few years we will see (1) ...
29 Although the remission duration was shorter with prior exposure to FLT3 tyrosine kinase inhibitors (TKIs), a trend toward a longer median OS in the gilteritinib arm was again observed among patients with prior TKI exposure. Another FLT3 inhibitor, quizartinib, was not approved by the FDA ...
They also discuss how the limitations of resources such as technology, effective treatments, and supportive care for patients affected their work and continue to do so. Additionally, the 3 experts explain the importance of having female mentors in a male-dominated field, the excitement th...
However, if long-term control of disease is desirable, hormonal therapy, NSAIDs, and TKIs are the likely treatments of choice. Recent new findings in the biologic development of these tumors, such as the role of Wnt/β-catenin dependent pathway, have shown that the prognostic information ...
Zhou, J.; Wang, J.; Zeng, Y.; Zhang, X.; Hu, Q.; Zheng, J.; Chen, B.; Xie, B.; Zhang, W.-M. Implication of epithelial-mesenchymal transition in IGF1R-induced resistance to EGFR-TKIs in advanced non-small cell lung cancer.Oncotarget2015,6, 44332–44345. [Google Scholar] [...
Currently, targeted therapies including tyrosine kinase inhibitors (TKIs) are regularly used. Others are still in development to achieve better results in this difficult-to-treat disease. 2. Kinome and Tyrosine Kinase Protein kinases play a key role in signal transduction. About 500 human genes ...
Moreover, it is clear that though some of the mutant Ph-positive subclones that develop in patients taking tyrosine kinase inhibitors (TKIs) are the direct cause of the resistance observed, in other cases, its cause is unclear. It is likely that in the n...