AlphaFold2 (AF2) provides a 3D structure for every known or predicted protein, opening up new prospects for virtually every field in structural biology. However, working with transmembrane protein molecules pose a notorious challenge for scientists, resulting in a limited number of experimentally determ...
After TAP transport, N-terminally extended MHC I pre- cursor peptides are trimmed by ER aminopeptidases to obtain a length fitting the MHC I peptide binding groove.23 Subsequently, the tapasin-MHC I interaction facilitates effi- cient loading of peptide ligands, thereby inducing a stable ...
The outcome of tumor treatment via hyperthermia in the clinic has been reported to be heterogeneous. Here, we assessed how the presence of gastrin-releasing peptide receptor (GRPR) and αvβ3 integrin together with the morphology of the vascularization r
In addition to receptors recognizing classical MHC I, NK cells express a large arsenal of prominent inhibitory and activating receptors (e.g., NKG2A, NKG2C, NKG2D;Table 1), that are capable of interacting with a broad spectrum of different ligands. Many of these are non-classical MHC I mol...