Establishment of gene" knock-out mice" is powerful to search the gene functions in vivo, However, some conventional "knock-out mice" have resulted in le- thality during embryogenesis or soon after birth, preventing analysis of gene functions in adulthood.Junji Takeda日本香粧品科学会誌...
讲座期间,龙教授围绕“How Do New Genes Evolve Expression Networks?”展开主旨报告,分享了他自20世纪90年代开创“新基因的起源和演化”领域以来,近30年里深耕该领域研究的心得与成果。报告从古基因、旧基因和青年基因的概念开始,通过介绍他对...
Understanding genetic innovation requires two questions to be addressed: which gene was involved in the duplication; and how has natural selection acted on that duplication to optimize the novel function? Genes with functions such as enzymes, transporters and transcription factors often survive in duplic...
Brill, S. J., DiNardo, S., Voelkel-Meiman, K. & Sternglanz, R. Need for DNA topoisomerase activity as a swivel for DNA replication for transcription of ribosomal RNA. Nature 326, 414–416 (1987). Article CAS PubMed Google Scholar Kim, R. A. & Wang, J. C. Function of DNA to...
P.1.03 How do genes exert their role? Period 3 gene variants and possible influences on mood disorder phenotypes E Marino,C Lorenzi,A Pirovano,... 被引量: 0发表: 2007年 Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder Bipolar affective disorder...
Researchers have taken advantage of the CRISPR system's ability to make precise cuts in DNA. Byadapting CRISPR to make desirable genome editsin any cell type, researchers can alter genes or DNA sequences that regulate genes' activity, changing their function or expression. ...
a. The structure and function of mutations and how they alter genetic traits. b. Genes and the DNA sequences between genes and how they determine development. c. The information provided by computer programs which analy What is the importance of understanding the human...
Like other species, we are the products of millions of years of adaptation. Now we're taking matters into our own hands.
Cells interact with the curved surfaces of many organs and, at a lower scale, with the rounded features of the extracellular matrix, which inherently links geometric form and biological function. The curvature of the extracellular matrix influences vital cellular processes by defining physical boundary...
et al. The birth of the epitranscriptome: deciphering the function of RNA modifications. Genome Biol. 13, 175 (2012). Article CAS PubMed PubMed Central Google Scholar Yue, Y., Liu, J. & He, C. RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation. Genes Dev...