Establishment of gene" knock-out mice" is powerful to search the gene functions in vivo, However, some conventional "knock-out mice" have resulted in le- thality during embryogenesis or soon after birth, preventing analysis of gene functions in adulthood.Junji Takeda日本香粧品科学会誌
讲座期间,龙教授围绕“How Do New Genes Evolve Expression Networks?”展开主旨报告,分享了他自20世纪90年代开创“新基因的起源和演化”领域以来,近30年里深耕该领域研究的心得与成果。报告从古基因、旧基因和青年基因的概念开始,通过介绍他对...
Understanding genetic innovation requires two questions to be addressed: which gene was involved in the duplication; and how has natural selection acted on that duplication to optimize the novel function? Genes with functions such as enzymes, transporters and transcription factors often survive in duplic...
activity (coding and non-coding), focus on a subset of relevant target genes and transcripts, or profile thousands of genes at once to create a global picture of cell function. Gene expression analysis studies can provide a snapshot of actively expressed genes and transcripts under various ...
Brill, S. J., DiNardo, S., Voelkel-Meiman, K. & Sternglanz, R. Need for DNA topoisomerase activity as a swivel for DNA replication for transcription of ribosomal RNA. Nature 326, 414–416 (1987). Article CAS PubMed Google Scholar Kim, R. A. & Wang, J. C. Function of DNA to...
Like other species, we are the products of millions of years of adaptation. Now we're taking matters into our own hands.
and another section of the data model may have one or none. The relationships between data entities exist in the database itself rather than in the code used to join tables (as you would do in a relational database). You can also create new relationships or add-on new datasets at any ...
Researchers have taken advantage of the CRISPR system's ability to make precise cuts in DNA. Byadapting CRISPR to make desirable genome editsin any cell type, researchers can alter genes or DNA sequences that regulate genes' activity, changing their function or expression. ...
This is really a question about how our bodies store and use the energy we need to function. It stood to reason, then, that somewhere in the brain leptin was being combined with other signals related to available energy, and that this information would then have to be compared with a home...
Reverse-engineering has many legitimate uses in IT. It can be both a legal and ethical approach to address compatibility issues, recreate legacy parts, do security assessments, improve upon an existing product or make it more inexpensively. ...