DNA is exposed to both endogenous and exogenous DNA damaging agents that chemically modify it. To counteract the deleterious effects exerted by DNA lesions, eukaryotic cells have evolved a network of cellular pathways, termed DNA damage response (DDR). The DDR comprises both mechanisms devoted to ...
The article discusses a study by Suhas Rao and colleagues in the journal "Cell" describing the creation of a three-dimensional (3D) map of the way genetic material folds and loops in on itself in order to fit into the cell nuclei, called the loopome.Wilson, ClareELSEVIERnew scientist...
our livers of liver cells, and there are even very specialized types of cells that make the enamel for our teeth or the clear lenses in our eyes!
And after the machinery has passed by, the nucleosomes are reassembled on the two resulting 'daughter' strands, which requires the addition of new histones.To make things more complicated, one of the two DNA strands can be replicated only in short pieces - called Okazaki fragments - that are...
DNA evidence has come so far so fast. The techniques that make it possible to identify a suspect using his or her unique genetic blueprint have only been around since 1985. That's when Alec Jeffreys and his colleagues in England first demonstrated the use of DNA in a criminal investigation...
When the cell reproduces, it must pass all of this information on to the daughter cells. Before a cell can reproduce, it must first replicate — or make a copy of — its DNA. Where DNA replication occurs depends upon whether the cell is a prokaryote or a eukaryote. DNA replication ...
COVID-19 is a reminder of their destructive power, but they’re crucial to humans’ development and survival.
how billions of biomolecules—like DNA, proteins, and lipids—come together to act as one cell. Nor do we know how our many types of cells interact within our bodies. We have limited understanding of how cells, tissues, and organs become diseased and what it takes for them to be healthy...
How is RNA formed from DNA? How do cells use the base sequence of a DNA molecule to produce a polypeptide? What type of cells have DNA inside a nucleus? How are DNA, protein, and carbohydrates involved in the structure of your cells?
How do cells help ensure that DNA replication is accurate? Does DNA polymerase 1 have exonuclease activity? Does DNA polymerase have exonuclease activity? Is telomerase a DNA polymerase? Why is DNA polymerase from thermus aquaticus ideal for PCR?