coli complexed with one of the most potent coumarin inhibitors, clorobiocin. Proteins 28, 41–52 (1997). Article CAS PubMed Google Scholar Classen, S., Olland, S. & Berger, J. M. Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic ...
S. mutansemploys some acid-resistant mechanisms to cope with the stress of increasing acid production. F1F0-ATPase, a proton pump encoded byatpD47, not only pumps out intracellular protons to maintain intracellular pH but also produces ATP to promote bacterial growth and survival53. Inhibition of...
Antiviral efficacy of nanoparticulate vacuolar ATPase inhibitors against influenza virus infection Int. J. Nanomed., 13 (2018), pp. 8579-8593 CrossrefView in ScopusGoogle Scholar [34] T.T. Tai, T.J. Wu, H.D. Wu, Y.C. Tsai, H.T. Wang, A.M. Wang, S.F. Shih, Y.C. Chen A ...
Alternatively, phenol/chloroform extraction and/or ethanol precipitation can be used to remove inhibitors from the DNA preparation. Improper reaction conditions Check that proper reaction conditions were used including the optimal buffer, temperature and amount of enzyme. Suggested reaction conditions can ...
However, it turned out that the blockade of the electrogenic function of the α2 subunit of Na+, K+-ATPase with a 1 µM of ouabain resulted in reduced RMP in muscle fibers of intact rats, but did not lead to a further decrease in RMP in the unloaded rats [79]...
Today we know some of the principles that govern ESCRT-III function, but a detailed picture of how it catalyzes fission in conjunction with the ATPase VPS4 is still lacking. The effect of ESCRT-III polymers on lipids and the generation or maintenance of membrane domains is yet unexplored. ...
Uptake of serotonin is an active process that is temperature-dependent and has an absolute requirement for external Na+ and C1−; it is inhibited by metabolic inhibitors as well as by inhibitors of Na/K ATPase activity. From these and other data, it has been inferred that the energy ...
Acid tolerance processes primarily rely on the involvement of F1F0-ATPase and AguD. Full size image Virulence factors The virulence factor of S. mutans can be categorized into four major groups, comprising EPS synthesis, adhesion, acid production, and acid resistance. The synthesis of EPS The ...
TAM receptors are pleiotropic inhibitors of the innate immune response. Cell 131, 1124–1136 (2007).This paper delineates a mechanism whereby AXL functions as an intrinsic negative feedback inhibitor of the innate immune response in DCs. CAS PubMed Google Scholar Chan, P. Y. et al. The ...
Even though the relationship between activation and structure remains to be further explored, structural studies provide a basis for developing drugs and inhibitors for therapeutic and research purposes. The recent discovery of NLRP3 cages creates a new and exciting avenue for this work. While the pr...