the researchers are injuring the carotid artery in mice with and without the genetic mutation then monitoring both recoveries. Stansfield notes that arterial stenosis is most common in the kidneys in NF1, but the carotid is a larger, more accessible...
Although NF1 is the most common genetic syndrome associated with multiple CALs, many others exist, such as Legius syndrome, multiple familial CALs, and other RASopathies (including Noonan syndrome, Noonan syndrome with multiple lentigenes, cardiofaciocutaneous syndrome, and Costello syndrome). Although...
However, in NF measurement, this is usually not a concern because the IF frequency used is between 50 and 150 MHz, and the leakage frequency is much higher (in this case, 18.368 GHz), above 3.6 GHz, so the internal filter of the signal analyzer will filter out the LO leakage, which w...
While people with NF1 usually come to medical attention for birthmarks on their skin, they are also at increased risk of developing tumors. One of the most common of these tumors in children is a low-grade brain tumor called an optic glioma, which affects the optic nerve that connects the...
This a type of tumor that grows on nerves of the spine. It's more common in people who have a condition calledneurofibromatosis type 1, or NF1. NF1 causes clusters of tumors to grow around the body, usually on or just under theskin. These tumors are not cancerous. ...
While people with NF1 usually come to medical attention for birthmarks on their skin, they are also at increased risk of developing tumors. One of the most common of these tumors in children is a low-grade brain tumor called an optic glioma, which affects the optic nerve that connects the...
Fig. 2. Common mechanisms of resistance to targeted therapies. Reactivation of the MAPK pathway (80% of resistance cases) and alternative pathways most commonly occurs via mechanisms involving activating mutations in genes involved in proliferation and survival, RAF-mediated resistance mechanisms, loss ...
Hereditary pNETs are frequently misdiagnosed because their presentation may mimic other more common diseases, resulting in diagnostic delays. Although non-operative (conservative) management could be advocated in select cases in most patients, hereby avoiding surgery without loss of oncological safety, ...
However, there is a paucity of data on this issue. Similar to Chumsri67 et al., our group previously showed that the APOBEC signature is the most common dominant mutational process associated with hypermutation in breast cancer, followed by the dMMR signatures62. The APOBEC family has ...
Renal artery stenosis is a common problem, particularly for patients with other manifestations of atherosclerosis. Wide practice variations are apparent re... SC Textor - 《J Hypertens Suppl》 被引量: 13发表: 2005年 Renal artery stenosis due to neurofibromatosis type 1: case report and literature...