For this reason, we will make use of analogies with existing forms of testing and screening, including testing and screening for monogenic subtypes of common complex disorders, whenever this seems appro- priate. Special cases such as hemochromatosis (monogenic, yet not highly penetrant) and familial...
Although they believe that this approach is not feasible for hemochromatosis, they conclude that a more appropriate group should be sought to validate their estimates based on cross-sectional data. In the breast and ovarian cancer review, no answers are given for questions 18, 19 and 23 (which...