The invention provides methods and compositions for identifying cancer stem cells and stem cells. In addition, β-catenin, hematopoietic tumors, ie been identified as a target for the therapeutic component development for leukemia and lymphoma cells, in this development, screening assays for β-...
Researchers at Johns Hopkins Medicine have identified a molecular pathway in human breast and lung cells that might lead to excessive genome duplication, a common feature in cancer cells. By studying the cell cycle, they discovered that certain proteins and enzymes behave abnormally under stress, p...
and cancer stem cells. The effectiveness of chemotherapy can be assessed clinically and pathologically. Clinical response evaluation is based on physical examination or imaging (mammography,ultrasonography,computed tomography scan, or magnetic resonance imaging) and includes tumor size changes after chemotherap...
Nanosensors that target lung cancer proteins can be aerosolized and delivered with an inhaler or nebulizer. The researchers tested this system in mice genetically engineered to develop human-like lung tumors. Using aerosol nebulizers, they delivered 20 sensors to mice with the equivalent of s...
TReg cells have multiple mechanisms at their disposal to mediate their suppressive effects. These can be grouped into four basic 'modes of action': suppression by inhibitory cytokines, suppression by cytolysis, suppression by metabolic disruption and suppression by modulation of dendritic-cell (DC) ma...
Single-nucleotide-resolution chemical RNA structure probing is emerging to explore the folding state of the transcriptome in living cells; the resulting models for how 5′ UTR structures impact translation should be validated by compensatory mutagenesis.Abstract...
Moles 101: How to self-examine your skin and monitor moles, with the alphabet test and tips from a doctor with a skin cancer specialism.
CD47 recognized by its macrophage receptor SIRPα serves as a “don’t eat-me” signal protecting viable cells from phagocytosis. How this is abrogated by apoptosis-induced changes in the plasma membrane, concomitantly with exposure of phosphatidylserine
PH, CO2/O2 levels). Once in optimal culture conditions, cells can be grown for different experimental analysis. With advancements in animal-cell-culture technology, cell lines have evolved and are also used for vaccine production, therapeutic proteins, pharmaceutical agents, and anti-cancer...
However, it seems it’s not as simple as that and cancer cells have other ways to escape the immune response. One is the production of the enzyme indoleamine-2,3-dioxygenase (IDO1), which converts tryptophan into kynurenine damaging the immune response in two ways: ...