The invention provides methods and compositions for identifying cancer stem cells and stem cells. In addition, β-catenin, hematopoietic tumors, ie been identified as a target for the therapeutic component development for leukemia and lymphoma cells, in this development, screening assays for β-...
Research led by David Litchfield of The University of Western Ontario has identified how biochemical pathways can be "rewired" in cancer cells to allow these cells to ignore signals that should normally trigger their death. It's one way that cancer cells may become resistant to therapy. The fin...
Cancer cells can hijack cell cycles to exponentially increase their numbers, a process called proliferation. Cancer drugs can stop the growth ofcancercells by jumpstarting a complex chain of genetic and cellular events. But often, this story is more complex, involving treatments that don't work a...
Mark Ratain and his team studied 61 colon cancer patients receiving irinotecan and learned that patients with ’alterations of the gene labeled as 7/7 were most likely to suffer severe losses of white blood cells. Patients with the 6/7 alteration type had intermediate side effects, and ...
Cancer is a rapidly growing burden on healthcare. To turn the tide, science and society must unite to accelerate therapeutic breakthroughs — and change the way they’re delivered.
However, it seems it’s not as simple as that and cancer cells have other ways to escape the immune response. One is the production of the enzyme indoleamine-2,3-dioxygenase (IDO1), which converts tryptophan into kynurenine damaging the immune response in two ways: ...
Dr. Diane Simeone, M.D. Director of NYU-Langone Pancreatic Cancer Center answers your questions about pancreatic cancer. By TraceySMay 7, 2021 Pancreatic Cancer Overviews Overview of Pancreatic Cancer Symptoms, risk factors, diagnosis, screening and prevention of pancreatic cance...
Defects and deficiencies in unconventional T cells are associated with autoimmunity, chronic inflammation and cancer, so it is important to understand how their development is regulated. In this Review, we describe the thymic development of NKT cells, MAIT cells and γδ T cells and highlight ...
A DNA damage that is not correct during the replication process can activate "oncogenes" that may progress to cancer. Discuss the normal DNA replication process, and explain how an uncorrected error would be passed to daughter cells. S...
PH, CO2/O2 levels). Once in optimal culture conditions, cells can be grown for different experimental analysis. With advancements in animal-cell-culture technology, cell lines have evolved and are also used for vaccine production, therapeutic proteins, pharmaceutical agents, and anti-cancerous agents...