Degenerate patterns of T cell receptor (TCR) recognition in which intralesional T cell clones presenting the same TCR-BVJB and AVJB and recognized different antigens are described. The production of inflammatory cytokines such as TNFa, IL-2, IL-17, IL-23 and IFNg from peripheral and heart-...
Recently, the MAXIMISE study described the co-occurrence of inflammatory and post-inflammatory changes of the bone marrow as assessed by FAt Spondyloarthritis Spine Score (FASSS), suggesting an inflammatory process similar to axSpA in axPsA [60]. More imaging studies are needed to understand better...
The auto-antigens are also presented by dendritic cells to stochastically generated autoreactive B cells in the germinal centers of secondary lymphoid organs (Fig.1E). Once activated, B cells expand, mature, and secrete auto-antibodies against nuclear antigens, a unifying feature of lupus (Fig....
Regulatory T cells (Tregs) are also a key part of the adaptive immune system that act as a critical off switch. They keep the immune response in check by suppressing the activity of T Cells to ensure that the immune system doesn’t overreact and attack self-antigens or other non-threateni...
The dental conditions in five patients who underwent radiation therapy for treatment of oral carcinomas are described. Differences in clinical appearance and behavior between radiation caries and ordinary dental caries are discussed. Rad... M Karmiol,RF Walsh - 《Journal of the American Dental Assoc...
S Pottmeyer,B Kemper - 《Journal of Molecular Biology》 被引量: 156发表: 1992年 The molecular basis of CD1-mediated presentation of lipid antigens. Summary: The CD1 family of proteins mediates a newly described pathway for presentation of lipids and glycolipids for specific recognition by T cel...
(neutrophil extracellular trap) formation is more advantageous during bacterial infections, whereas DC-like functions such as antigen presentation are essential upon viral recognition. Indeed, using in vitro assays, the authors found NeuMo to display superior migration and NET formation capacities, while ...
作者: Ohno,S.摘要: Class I major histocompatibility complex (MHC) antigens are confronted with an apparently insurmountable dilemma. Each should show a binding preference to a common enough variety of nonapeptides, so that one relevant nonapeptide can be found in at least every other viral ...
The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. This work was also supported by Core Clinical Trials Unit Infrastructure from Cancer Research UK [C7852/A25447]. IRW was supported by the Medical Research ...
(ab′)2are described in Chapter 151. Fab′ fragments are then prepared from the two F(ab′)2species by reduction with thiol, thus exposing free SH groups at the hinge region (three SH-groups for mouse IgG1 and IgG2a antibodies) (seeNote 1). One of the FabЭ species (Fab′-A) is...