We demonstrate that the neuronal-enriched HOTAIRM1 isoform epigenetically controls the expression of the proneural transcription factorthat is key to neuronal fate commitment and critical for brain development. We also show that HOTAIRM1 activity impacts on NEUROGENIN 2 downstream regulatory cascade, ...
沉默lncRNA Hotairm1通过靶向miR -129-5p 可减轻H/R 诱导的心肌细胞氧化应激损伤和细胞凋亡,发挥心肌保护作用㊂关键词 氧化应激损伤;缺氧/复氧;长链非编码RNA Hotairm1,lncRNA Hotairm1;miR -129-5p ;凋亡d o i :10.12102/j.i s s n .1672-1349.2023.11.008 Effects of lncRNA Hotairm1Targeting ...
HOTAIRM1 (HOX antisense intergenic RNA myeloid 1) is a long non-coding RNA gene. In humans, it is located between the HOXA1 and HOXA2 genes. HOTAIRM1 is expressed in cells of a myeloid lineage, and may play a role in myeloid transcriptional regulation.Long non-coding RNAs (long ncRNAs...
HOXA transcript antisense RNA myeloid-specific 1 (HOTAIRM1) is a long non-coding RNA (lncRNA) that plays a pivotal role in regulating myeloid cell development via targeting HOXA1 gene expression. We and others have previously shown that myeloid-derived s
HOTAIRM1JNK/c‐Jun signallingosteogenesisp300Mesenchymal stem cells (MSCs) have potential ability to differentiate into osteocytes in response to in vitro specific induction. However, the molecular basis underlying this biological process remains largely unclear. In this study, we identify lncRNA HOT...
HOTAIRM1表达量和胃癌患者的临床病理学特征相关性分析采用Fisher's确切概率法检验,生存分析采用在线生存分析网站所自带的统计软件分析.结果 在胃癌患者正常组织中的HOTAIRM1的表达水平显著低于胃癌癌组织(1.00±0.24比2.12±0.39,t=2.722,P<0.05);胃癌癌组织中HOTAIRM1的表达水平与分化程度呈明显负相关(x2=5.749,P<...
HOTAIRM1表达量与NSCLC各亚组患者的生存期是否存在相关性.结果:1,qRT-PCR显示,95例NSCLC患者,LncRNA-HOTAIRM1在癌组织中的相对表达量为2.364±2.178,在癌旁组织中的相对表达量为1.001±0.9524,与癌旁组织相比较,LncRNA-HOTAIRM1在NSCLC癌组织中高表达(P0.0001).36例肺腺癌患者,癌组织中LncRNA-HOTAIRM1的相对...
HOTAIRM1 was overexpressed in PC3 cells compared with RWPEcells. Reducing HOTAIRM1 alleviated cell proliferation and increased apoptosis of PC3 cells so that the expression of pro゛poptotic agents such as Bad and Bax was significantly increased, while that of Bid and Bcl(anti゛poptotic) was ...
HOTAIRM1抑制EGR1蛋白表达而不影响其m RNA表达;MDM2作为E3泛素连接酶介导EGR1蛋白的泛素化修饰;HOTAIRM1作为支架分子增强MDM2和EGR1相互作用,促进MDM2对EGR1的泛素化修饰,导致EGR1蛋白水平下调.(5)过表达EGR1抑制白血病细胞自噬,增殖和周期进程,促进细胞凋亡;回复实验结果进一步表明EGR1在HOTAIRM1促进白血病细胞存活...