functional host-targeting antiviral for hepatitis D virus has been approved.Despite the availability of effective antivirals, a prophylactic vaccine is essential for preventing HCV reinfections.Contraindications and treatment failures in chronic HEV therapy emphasize the urgent need for further antiviral ...
The design of host-targeting antivirals (HTA) represents another challenging field of HCV therapeutics development. HTAs inhibit the function of cellular factors critical for HCV replication. Such approaches are expected to increase the barrier to resistance since host genes are not subjected to the ...
host-targeting antivirals (HTAs); DHODH inhibitors (DHODHi); pyrimidine synthesis; broad-spectrum antivirals1. Introduction In recent years, emerging or re-emerging viruses have appeared with increasing frequency, severely threatening global public health security and causing enormous economic losses [1...
Keywords: hepatitis C virus; host-targeting agent; direct-acting antiviral; viral resistance 1. Introduction Hepatitis C virus (HCV) is a hepatotropic enveloped RNA virus of the Flaviviridae family. It is a highly variable virus that has been classified into six major genotypes [1]. ...
SARS-CoV-2 viral proteins interact with the eukaryotic translation machinery and inhibitors of translation have potent antiviral effects. Here we report that the drug plitidepsin (aplidin), which has limited clinical approval, possesses antiviral activity (IC90 = 0.88 nM) 27.5-fold more potent tha...
R. et al. Development of CRISPR as an antiviral strategy to combat SARS-CoV-2 and influenza. Cell 181, 865–876.e12 (2020). Article CAS PubMed PubMed Central Google Scholar Kumar, A. et al. Genome-wide gene expression pattern underlying differential host response to high or low ...
As the FIASMA group consists of a large number of small compounds that are well-tolerated and widely used for a broad range of clinical applications, exploring these licensed pharmaceuticals may offer a variety of promising antivirals for host-directed therapy to counteract SARS-CoV-2 and COVID...
To target the ER or Golgi network, different secreted effectors evolved to specifically hijack RAB proteins and exploit phosphoinositide lipids, which are phosphorylated derivatives of phosphatidylinositol. Mitochondria are the power plants of the cell, but are also involved in essential cellular processes...
As well known, the JAK/STAT signaling pathway is highly conserved from vertebrates to invertebrates and plays an important role in the antiviral immune response29,33. The activation of STAT, the transcription factor of JAK/STAT signaling pathway, triggers expressions of the effect genes. However,...
While the road to developing host-targeting antivirals has been less traveled, and significant challenges remain, delivering the most effective antiviral regimen, which may comprise inhibitors of both host and viral targets, should be well worth the effort....