Recent updates on research models and tools to study virus-host interactions at the placentadoi:10.3390/v12010005Jae Kyung LeeSoo Jin OhHosun ParkOk Sarah ShinViruses
is an emerging tick-borne disease with high mortality rates caused by the SFTS virus. Here, the authors identify LRP1 as an entry factor for SFTSV, show that SFTSV glycoprotein Gn interacts with LRP1 and that blocking LRP1 reduces viral infection and improves survival in lethal mouse models....
Human stem cell models to study host–virus interactions in the central nervous systemMedical and Health SciencesMedical MicrobiologyNeurosciencesAdvancements in human pluripotent stem cell technology offer a unique opportunity for the neuroimmunology field to study host鈥搗irus interactions directly in ...
The k-mers of 4 nucleotides were selected (Additional file 1: Figure S2), which resulted in 256 features. The GM was built using the function of GaussianMixture in scikit-learn [25, 26]. Definition of accuracy in virus host prediction by Gaussian models For each virus, the GM calculated ...
However, little work has been done using these models to examine the cell-level mechanisms of H9N2 AIV infections in chickens (Hagenaars et al., 2016). A model that can reproduce respiratory and cloacal virus shedding patterns, as well as host antibody responses would be a valuable tool for...
(NCLDVs). A monophyletic group of ten virus families that have a common virion and genomic structure and replicate in the nucleus of their hosts, but their particles form in the host cytoplasm. Phycodnavirus One of a family of nucleocytoplasmic large DNA viruses that commonly infects marine ph...
[67–70]. They have been used successfully for infection studies with all known human coronaviruses [56,57]. Furthermore, the cultures can be inoculated with a low infectious dosage to mimic natural infection in the human airway. Whereas, animal models often require both high dosage and ...
Our systematic review includes both types of studies (Case report studies for inborn errors of immunity and GWAS studies). Immune response to SARS-CoV-2 can be divided into two phases. In the first phase, the body tries to eliminate the virus using regulated immune response in the early ...
Viruses are obligate intracellular pathogens that cause infection in susceptible host cells. Virus infections could be lytic, chronic, latent or immortalizing. Viruses causing latent infection are associated with high morbidity and mortality worldwide. T
Genetic disposition can impact response to virus infection. Here, the authors used a reinfection approach with antigenically distinct SARS-CoV-2 variants Omicron and Beta and show that differences in the immune response correlate with disease outcome in mouse models with different genetic background upo...