All of the physiologically active steroids of the adrenal cortex affect the metabolism of water and electrolytes. The term “mineralocorticoids” has been used conventionally to designate those steroids such as deoxycorticosterone (DOC) and...
For this reason, modifications of peptide-based drug candidates increasing their metabolic stability and bioavailability, and retaining their functions are of high demand. Several significant achievements have been made, such as the introduction of non-proteinogenic amino acids, cyclization, modifications ...