receptor–ligand complexes undergo conformational changes that culminate in direct and/or indirect interactions with gene transcription and/or mRNA half-life of a wide variety of genes, resulting in potentially profound changes in the assortment of proteins available to receptive cells(1). Given their...
The present study shows that canine and feline mammary tumors, like human breast tumors, can be polyreceptive, i.e., they can contain estrogen (ER), progestin (PR), androgen, glucocorticoid, and/or mineralocorticoid cytosol receptors. Furthermore, a follow-up of 45 bitches with mammary ...
and then they exposed those extracted plastic chemicals toMCF-7 cells, a type of human breast cancer cell that is receptive to estrogen. If the cells multiplied in the presence
In contrast to gonadotropes, in which the majority expressed ERs, few somatotropes were estrogen receptive. These data suggest that estrogen does not act directly on GHRH neurons to influence GH secretion, and any direct effect on pituitary GH release, through the ERalpha, may be small. 展开...
1. any of various internally secreted compounds formed in endocrine glands that affect the functions of specifically receptive organs or tissues when transported to them by the body fluids. 2. a synthetic substance that acts like such a compound when introduced into the body. 3. any of vario...
120 Canine mammary cancers as animal models for hormone-dependent human breast tumors: Relationship between steroid receptor profiles and survival ratesThe present study shows that canine and feline mammary tumors, like human breast tumors, can be polyreceptive, i.e., they can contain estrogen (ER...
It was also shown to be highly expressed in receptive endometrial RL95-2 cells compared with non-receptive HEC1-A cells [58]. Moreover, the expression of THBS1 in Ishikawa cells was shown to be regulated by progesterone [59]. Decreased THBS1 expression in decidua macrophages was associated ...