The hormone enters the cell, binds to the cytoplasmic receptor, which after activation translocates to the nucleus. The hormone-receptor complex in turn binds to nuclear acceptor sites on the chromatin. This activates a variety of metabolic processes, one of the most important being the stimulation...
The mechanism ofsteroid hormoneaction is thought to involve specific high-affinityreceptor proteins. The hormone enters the cell, binds to thecytoplasmic receptor, which after activation translocates to the nucleus. The hormone-receptor complex in turn binds to nuclearacceptor siteson the chromatin. Thi...
Dio3 was expressed throughout the cell cycle in progenitor cells. TRa was in most, if not all, retinal cells. Dio2 appeared transiently in a ventral (high) to dorsal gradient, likely in a subset of photoreceptor cells. Conclusion Multiple TH components were expressed in dynamic patterns in ...
Which of the following substances enters the cell, binds to an internal receptor, and stimulates DNA synthesis to have its effect? a. Triiodothyronine (T3). b. Epinephrine. c. Insulin. d. Thyrocalcitonin. e. None of the above. Which o...
Thyroid hormone (TH) regulates many functions including metabolism, cell differentiation, and nervous system development. Alteration of thyroid hormone level in the body can lead to nervous system-related problems linked to cognition, visual attention, v
SARS-CoV-2 enters host cells via ACE2, which is highly expressed in the heart, kidney and lung and shed into plasma [5]. Compared with women, men have a higher incidence, severity, and mortality from COVID-19 [6], but the underlying factors contributing to this sex difference are ...
When food enters the stomach, the wall of its pyloric end (the area at which the stomach joins the small intestine) releases gastrin, which promotes the flow of acid from the gastric glands in the stomach. These glands also release pepsinogen, which is the inactive form of the protein-diges...
In expression from eukaryotic cells, these sequences are enzymatically removed, such that the hormone enters the periplasmic space in its free, bioactive form. However, microbial cells cannot be relied upon to perform that function, and it is accordingly desirable to remove sequences coding for ...
Danielsen et al., “The mouse glucocorticoid receptor: mapping of functional domains by cloning, sequencing and expression of wild-type and mutant receptor proteins”, The EMBO Journal vol. 5:2513-2522 (1986). Northrop et al., “Analysis of Glucocorticoid Unresponsive Cell Variants Using a Mous...
From here, there are two pathways that proteins can take to the cell surface, depending on the cell type. Proteins can be transported directly to the plasma membrane (constitutive secretion) or to secretory granules (regulated secretion). See Endoplasmic reticulum, Golgi apparatus In all cells, ...