its presence at a locus will super-cede any recessive alleles. These systems are very common in Mendelian genetics with Punnett Squares, where – for example – the alleles AA and Aa would exhibit the dominant gene, while
Reinforcing the central role of RAD51 in HR and KI events following targeted double-strand breaks, fusion of RAD51 to Cas9, which has a dominant-negative effect on endogenous RAD51 function, inhibits HDR (Rees et al., 2019). Based on the aforementioned findings and the key role of RAD51...